Personal Information

Zhangyuan Pan

Ph.D / Professor

Institute of Animal Science (IAS)

Chinese Academy of Agricultural Sciences (CAAS)

Address: No.2, Yuanmingyuan West Rd., Beijing 100193, China

Major: Animal Genetics and Breeding

Birth Date: Oct 9, 1986

Positional Titles

Postdoctoral of the University of California, Davis.

Young talents (overseas) of Chinese Academy of Agricultural Sciences.

Scientist, mutton sheep and goat genetics and breeding team, Science and Technology Innovation Project of China.

Major Leader of International FarmGTEx and Principal Executive of International Functional Annotation of Animal Genomes (FAANG).

Member of the Academic Bridge Review Expert of Chinese Society of Educational Development Strategy (CSEDS).

Editorial committee member of Epigenetics, BMC Genomics, Animal Biotechnology.

Education Background

Zhangyuan Pan received his BSc degree in Bioengineering (2009) from Huzhou University, Zhejiang, China. His MS degree in Animal Genetic Breeding & Reproduction (2012) from Yangzhou University, Jiangsu, China. His Ph.D. in Animal Genetic Breeding & Reproduction (2016) from Chinese Academy of Agricultural Sciences, Beijing, China. And he worked as a Postdoc at University of California, Davis, Animal Science Department from 2018 to 2022.

Research Area

Zhangyuan Pan majority focus on animal epigenomics. He is mainly engaged in the research of livestock and poultry functional target mining and analysis. He has proposed different research strategies for genetic regions, regulatory regions and cross-species conserved regions by using the interdisciplinary intersection of genomics, epi-genomics, bioinformatics and molecular biology. He constructed and improved the regulatory element maps of several livestock and poultry species, broke the SNP Linkage Disequilibrium, and significantly improved the mining efficiency of regulatory targets in non-coding regions. He also works on cross-species comparison and try to promote the cross-species application of conserved functional targets. To date, he identified a number of functional targets related to traits such as horn, tail fat, daily weight gain, and disease resistance. He presided and participated in many national natural science funds and undertaken several international collaborative projects. He was invited as a speaker in the International Society for Animal Genetics Conference (ISAG, 2021) and the Plant & Animal Genome Conference (PAG, 2022), and won the "Best Academic Poster Award". He has published 18 papers as first author in top journals such as Nature Communications (IF=17.69), Science Advances (IF=14.14), Genome Biology (IF=17.906) (co-first-author), GigaScience (IF=7.267), BMC Genomics (IF=3.594) and handed 5 national invention patents.

Ongoing Research Projects

(1) National Key R & D Project (Jan 2023 - Dec 2027) “The formation and evolution mechanism of excellent germplasm resources of main agricultural animals-Excavation and functional study of genes and loci related to excellent traits of main agricultural animals”.

(2) Biological Breeding Program (Jan 2023 - Dec 2023).

(3) National Natural Science Foundation of China (31802031, Jan 2019 - Dec 2021), “The affecting mechanism of RXFP2 gene E641K on the growth and development of ovine horn”.

(4) Shandong Natural Science Foundation of China (ZR2018BC045, Mar 2018 - Jun 2020), “The mechanism of RXFP2 regulating the proliferation and differentiation of horn cells in Small Tail Han sheep”.

Representative Papers

(1) Zhangyuan Pan#, Ying Wang#, Mingshan Wan#, Yuzhe Wang#, Xiaoning Zhu, Shenwen Gu, Conghao Zhong, Liqi An, Mingzhu Shan, Joana Damas, Michelle M. Halstead, Dailu Guan, Nares Trakooljul, Klaus Wimmers, Ye Bi, Shang Wu, Mary E. Delany, Xuechen Bai, Hans.H. Cheng, Congjiao Sun, Ning Yang, Xiaoxiang Hu, Harris A Lewin, Lingzhao Fang*, Huaijun Zhou*. An atlas of regulatory elements in chicken: a resource for chicken genetics and genomics. Science Advances, 2023, 9(18):ade1204 (IF= 14.14)

(2) Zhangyuan Pan#, Yuelin Yao#, Hongwei Yin, Zexi Cai, Ying Wang, Lijing Bai, Colin Kern, Michelle Halstead, Kelly Chanthavixay, Nares Trakooljul, Klaus Wimmers, Goutam Sahana, Guosheng Su, Mogens Sandø Lund, Merete Fredholm, Peter Karlskov-Mortensen, Catherine W. Ernst, Pablo Ross, Christopher K. Tuggle, Lingzhao Fang*, Huaijun Zhou*. Pig genome functional annotation enhances the biological interpretation of complex traits and human disease. Nature Communications, 2021, 12(1):5848. (IF= 17.69)

(3) Zhangyuan Pan#, Shengdi Li#, Qiuyue Liu#, Zhen Wang, Zhengkui Zhou, Ran Di, Benpeng Miao, Wenping Hu, Xiangyu Wang, Xiaoxiang Hu, Ze Xu, Dongkai Wei, Xiaoyun He, Liyun Yuan, Xiaofei Guo, Benmeng Liang, Ruichao Wang, Xiaoyu Li, Xiaohan Cao, Xinlong Dong, Qing Xia, Hongcai Shi, Geng Hao, Jean Yang, Cuicheng Luosang, Yiqiang Zhao, Mei Jin, Yingjie Zhang, ShenjinLv, Fukuan Li, Guohui Ding, Mingxing Chu*, Yixue Li*. Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization, GigaScience, 2018, 7(4):giy019. (IF=7.267)

(4) Yuelin Yao#, Shuli Liu#, Charley Xia#, Yahui Gao#, Zhangyuan Pan#, Oriol Canela-Xandri, Ava Khamseh, Konrad Rawlik, Sheng Wang, Bingjie Li, Yi Zhang, Erola Pairo-Castineira, Kenton D'Mellow, Xiujin Li, Ze Yan, Cong-jun Li, Ying Yu, Shengli Zhang, Li Ma, John B. Cole, Pablo J. Ross, Huaijun Zhou, Chris Haley, George E. Liu*, Lingzhao Fang*, Albert Tenesa*. Comparative transcriptome in large-scale human and cattle populations. Genome Biology, 2022, 23:176. (IF= 17.906)

(5) Colin Kern, Ying Wang, Xiaoqin Xu, Zhangyuan Pan, Michelle Halstead, Ganrea Chanthavixay, Perot Saelao, Susan Waters, Ruidong Xiang, Amanda Chamberlain, Ian Korf, Mary E. Delany, Hans H. Cheng, Juan F. Medrano, Alison L. Van Eenennaam, Chris K. Tuggle, Catherine Ernst, Paul Flicek, Gerald Quon, Pablo Ross*, Huaijun Zhou*. Functional annotations of three domestic animal genomes provide vital resources for comparative and agricultural research. Nature Communications, 2021, 12(1): 1821. (IF= 17.69)

(6) Zhangyuan Pan, Xiangyu Wang, Ran Di, Qiuyue Liu, Wenping Hu, Xiaohan Cao, Xiaofei Guo, Xiaoyun He, Shengjin Lv, Fukuan Li, Hui Wang, Mingxing Chu. A 5-methylcytosine site of growth differentiation factor 9 (GDF9) gene affects its tissue-specific expression in sheep. Animals, 2018, 8(11): 200. (IF= 2.323)

(7) Zhangyuan Pan#, Shengdi Li#, Qiuyue Liu, Zhen Wang, Zhengkui Zhou, Ran Di, Xuejiao An, Benpeng Miao, Xiangyu Wang, Wenping Hu, Xiaofei Guo, Shenjin Lv, Fukuan Li, Guohui Ding, Mingxing Chu*, Yixue Li*. Rapid evolution of a retro-transposable hotspot of ovine genome underlies the alteration of BMP2 expression and development of fat tails. BMC Genomics, 2019, 20(1):261. (IF= 3.594)

(8) Zhangyuan Pan, Zijie Zhang, Jiuxiu Ji, Huazhen Li, Anfang Sun, Fukuan Li, Hui Wang, Mingxing Chu*, Shenjin Lv*. Analysis of tissue expression pattern and potential functional sites of sheep INSL3 gene. Acta Veterinaria et Zootechnica Sinica. 2020, 51(4):679-687.

(9) Zhangyuan Pan, Xiaoyun He, Xiaofei Guo, Qiuyue Liu, Wenping Hu, Ran Di, Xiangyu Wang*, Mingxing Chu*. Application of whole genome sequencing in population evolution and functional gene mining of livestock and poultry. Journal of Agricultural Biotechnology. 2016, 24(12):1945-1954.

(10) Zhangyuan Pan, Xiaoyun He, Xiangyu Wang, Xiaofei Guo, Xiaohan Cao, Wenping Hu, Ran Di, Qiuyue Liu*, Mingxing Chu*. Research progress on selection signal of domestic animals. Hereditas (Beijing), 2016, 38(12):1069-1080.

Patents

（1）Mingxing Chu, Zhangyuan Pan, Qiuyue Liu, Ran Di, Wenping Hu, Xiangyu Wang, Xiaohan Cao. SNP marker combination of RXFP2 gene related to sheep horn phenotype and its application. ZL201511023518.8.

（2）Zhangyuan Pan, Fukuan Li, Shenjin Lv, Mingji Wei, Zhennan Wang, Peiming Sun. A craniotomy method for obtaining a complete sheep brain. ZL201710083059.5.

（3）Zhangyuan Pan, Shenjin Lv, Fukuan Li, Mingxing Chu, Hui Wang. A SNP molecular marker associated with sheep tail type and its application. ZL201711303789.8.

（4）Zhangyuan Pan, Shenjin Lv, Fukuan Li, Mingxing Chu, Hui Wang. A SNP molecular marker related to sheep tail width and its application. ZL201711303786. 4.

（5）Zhangyuan Pan, Shenjin Lv, Fukuan Li, Mingxing Chu, Hui Wang. A SNP molecular marker related to sheep tail length and its application. ZL201711303812.3.

Contact Ways

Tel: +86-10- 62816001, 13671099320

Fax: +86-10-62895351

E-mail: panzhangyuan@caas.cn, zhypan01@163.com

Website: https://ias.caas.cn