Personal information
Tu Tao, born in July 1988, Jingzhou City, Hubei Province, Doctor, Associate researcher, doctoral supervisor. In 2016, he received his Doctor of Science degree in Biochemistry and Molecular Biology from the Chinese Academy of Agricultural Sciences. From 2016 to 2020, he worked at the Feed Research Institute of the Chinese Academy of Agricultural Sciences. From 2020 to now, he worked at Institute of Animal Science of the Chinese Academy of Agricultural Sciences. He is mainly engaged in the research on the relationship between structure and function of feeding enzymes, and is currently the backbone expert of feeding enzyme engineering scientific and technological innovation team. He has been selected as a recipient of the Outstanding Young Scientists Fund (National Natural Science Foundation of China) and the winner of the Young Scientist Project of the National Key Research and Development Program (2021).
Research direction and results
He has been engaged in the research work related to feed enzyme engineering. By integrating the molecular biology, structural biology and bioinformatics technologies of feed enzymes, and studying the relationship between the structure and function of feed enzymes, he is committed to solving the fundamental problems of poor performance of feed enzymes and difficulty in meeting the needs of feed industry applications. He has presided over 9 scientific research projects and published 75 scientific research papers, of which 27 SCI indexed papers were published as the first author or corresponding author (including co-authors). Applied for 35 national invention patents (including 4 PCT patents) as the main author, and obtained 21 authorized patents.
Research project
National Natural Science Foundation of China Outstanding Youth Sciences Fund Project, 2023.01-2025.12, 2 million yuan, hosted
Young Scientist Project of National Key Research and Development Program, 2021.07-2024.06, 4 million yuan, hosted
Project of National Natural Science Foundation of China, 2021.01-2024.12, 69600 yuan, hosted
Representative papers
Ding S., Liu X., Hakulinen N., Taherzadeh M. J., Wang Y., Wang Y., Qin X., Wang X., Yao B., Luo H., Tu T.* Boosting enzymatic degradation of cellulose using a fungal expansin: Structural insight into the pretreatment mechanism. Bioresource Technology 2022, 358: 127434.
Wang S.,† Ding S.,† Meng K., Liu X., Wang Y., Wang X., Qin X., Luo H., Yao B., Huang H.*, Tu T.* Preparation of methyl-esterified pectin oligosaccharides with antibacterial activity using fungus-derived bifunctional pectinase. Journal of Cleaner Production 2022, 333: 130110.
Liang Z., Yan Y., Zhang W., Luo H., Yao,B., Huang H.*, Tu T.* Review of glucose oxidase as a feed additive: production, engineering, applications, growth-promoting mechanisms, and outlook. Critical reviews in biotechnology 2022, DOI: 10.1080/07388551.2022.2057275.
Wang Q., Liu X., Tian J., Wang Y., Zhang H., Wang Y., Luo H., Yao B., Huang H.*, Tu T.* Enhancing the thermostability of phytase to boiling point by evolution-guided design. Applied and Environmental Microbiology 2022, e0050622. (Featured Image)
Sun L., Bai Y., Zhang X., Zhou C., Zhang J., Su X., Luo H., Yao B., Wang Y.*, Tu T.* Characterization of three glutamate decarboxylases from Bacillus spp. for efficient γ-aminobutyric acid production. Microbial Cell Factories 2021, 20: 153.
Wang S.,† Meng K.,† Su X., Hakulinen N., Wang Y., Zhang J., Luo H., Yao B., Huang H.*, Tu T.* Cysteine engineering of an endo-polygalacturonase from Talaromyces leycettanus JCM 12802 to improve its thermostability. Journal of Agricultural and Food Chemistry 2021, 69, 6351−6359.
Tu T., Wang Z., Luo Y., Li Y., Su X., Wang Y., Zhang J., Rouvinen J., Yao B., Hakulinen N.*, Luo H.* Structural insights into the mechanisms underlying the kinetic stability of GH28 endo-polygalacturonase. Journal of Agricultural and Food Chemistry 2021, 69(2):815-823.
Jiang X., Wang Y., Wang Y., Huang H., Bai Y., Su X., Zhang J., Yao B., Tu T.*, Luo H.* Exploiting the activity-stability trade-off of glucose oxidase from Aspergillus niger using a simple approach to calculate thermostability of mutants. Food Chemistry 2021, 342:128270.
Ren Y., Luo H., Huang H., Hakulinenc N., Wang Y., Wang Y., Su X., Bai Y., Zhang J., Yao B., Wang G.*, Tu T.* Improving the catalytic performance of Proteinase K from Parengyodontium album for use in feather degradation. International Journal of Biological Macromolecules 2020, 154:1586-1595.
Tu T., Wang Y., Huang H., Wang Y., Jiang X., Wang Z., Yao B., Luo H. Improving the thermostability and catalytic efficiency of glucose oxidase from Aspergillus niger by molecular evolution. Food Chemistry 2019, 281:163-170.
Contact information
Contact number: 010-62599910 E-mail: tutao@caas.cn