Honglian Zhang, Ph.D, Associate Professor, Master Supervisor
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences (CAAS)
Research Interests: Efficient production of immunologically active proteins used in animal husbandry and exploring its mechanism
Email: zhanghonglian@caas.cn
Tel: 010-62599910
Address: No 2, Yuanmingyuan West Rd., Beijing, 100193, P.R. China
Update date: June 20, 2023
Biography
1990-1995 B.D. Wuhan Polytechnic University
1999-2002 M.D. Graduate School of the Chinese Academy of Agricultural Sciences
2006-2009 Ph.D. University of Chinese Academy of Sciences
2002-2011 Research associate and Assist and Associate Professor, Institute of Biophysics, Chinese Academy of Sciences
2012-2016 Senior Fellow, Mayo Clinic, USA
2017-2021 Associate Professor, Institute of Genetics and Developmental biology, Chinese Academy of Sciences
2021- Associate Professor, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences (CAAS)
Research Interests
Our research mainly focuses on efficient production of immunologically active proteins used in animal husbandry and exploring its mechanism. Specifically, we use the microbial expression system such as Escherichia coli and Pichia pastoris to efficiently heterogenous express immunologically active proteins used in animal husbandry for industrial application, such as antimicrobial peptides and animal vaccine et al. In addition, we also explore the mechanism of immunologically active proteins on enhancing animal immunity through molecular biology, cell biology, multi-dimensional omics, and immunology. Over 20 papers were published in high-profile journals such as Molecular Cell, Genes Dev., Cell Discovery, Cell Death Diffe., Science China Life science, Applied Microbiology and Biotechnology, Microbial Biotechnology, Cell and Sience as first author, corresponding author or co-author.
On-going Research Projects
Presiding over the general Program of the National Natural Science Foundation of China, research on the mechanism of H3K27me3 inhibiting DNA methylation (No.32070607)
Presiding over the Strategic Priority Research Program of the National Center of Technology Innovation for Pigs (No. NCTIP-XD/C07)
Selected Publications
Lu, Z. #, Liu, N. #, Huang, H., Wang, Y., Tu, T., Qin, X., Wang, X., Zhang, J., Su, X., Tian, J., Bai, Y., Luo, H., Yao, B., Zhang, H*. (2023) Recombinant expression of IGF‑1 and LR3 IGF‑1 fused with xylanase in Pichia pastoris.Applied Microbiology and Biotechnology. (In press)
Wang, X.#, Qin, X. #, Tong, L., Zheng, J., Dong, T., Wang, X., Wang, Y., Huang, H., Yao, B., Zhang, H *, Luo, H *. (2023) Improving the catalytic activity of a detergent-compatible serine protease by rational design. Microbial Biotechnology. 16(5): 947-960
Zhang, H. #, Liu, Y. #,Xie, Y. #, Zhu, Y. #, Liu, J., Lu, F. * (2022)H3K27me3 shapes DNA methylome by inhibiting UHRF1-mediated H3 ubiquitination.Science China Life science.65(9): 1685-1700
Fan, C. #, Zhang, H. #, Fu, L., Li, Y., Du, Y., Qiu, Z., Lu, F. * (2020)Rett mutations attenuate phase separation of MeCP2. Cell Discovery. 6(1): 38
Zhang, H. #, Gan, H. #, Wang, Z. #, Lee, J., Zhou, H., Ordog, T., Wold, M., Ljungman, M., Zhang, Z. * (2017) RPA interacts with HIRA and regulates H3.3 deposition at gene regulatory elements in mammalian cells. Molecular Cell. 65(2) : 272-284
Wang, Z. #, Zhang, H. #, Liu, J., Cheruiyot, A., Lee J., Ordog, T., Lou, Z., You Z., Zhang, Z. * (2016) USP51 deubiquitylates H2AK13, 15ub and regulates DNA damage response. Genes Dev.30(8) : 946-959
Liu, S. #, Zhang, H. #, Li, M., Hu, D., Li, C., Ge, B., Jin, B., Fan, Z. * (2013). Recruitment of the adaptor Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells. Cell Death Differ. 20 (3):456-464.
Fang, D.#, Gan, H.#, Lee, J.#, Han, J.#, Wang, Z.#, Riester S., Jin, L., Chen, J., Zhou, H., Wang, J., Zhang, H., Yang, N., Bradley, E., Ho, T., Rubin, B., Bridge, J. Thibodeau, S., Ordog, T., Chen, Y., van Wijnen, A., Oliveira, A., Xu, R., Westendorf, J., Zhang, Z.* (2016) The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science. 352(6291) : 1344-1348
Han, J., Zhang, H., Zhang, H., Wang, Z., Zhou, H., Zhang, Z. *(2013) A Cul4 E3 ubiquitin ligase regulates Histone hand-off during nucleosome assembly. Cell. 155(4):817–829
Wu, R., Wang, Z., Zhang, H., Gan, H., Zhang, Z. * (2016) H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication. Nucleic Acids Res.45(1): 169-180