Name: Yong Zhao

Titel: Professor

Specialty: Animal nutrition

Research area: Nutrition, gut microbiota and male fertility

Phone: 86-10-62816013

Email: zhaoyong1688@caas.cn

I got B.S. in Agronomy from Shandong Agricultural University in 2000; M.S. in Biochemistry and Molecular Biology from Chinese Academy of Agricultural Sciences in 2004; Ph.D. in Pharmaceutical Science from South Dakota State University (USA) in 2008. I had been the Post-Doctoral Research Fellow in Michigan State University (USA) from 2008 to 2013. I had been the Professor in the College of Life Sciences of Qingdao Agricultural University from 2013-2021. I am the Professor in the Institute of Animal Sciences of Chinese Academy of Agricultural Sciences from 2021.

As independent PI, I have had being in charge of almost ten grants including: the National Natural Science Foundation of China, the Returned Overseas Studies Fund Program of the Ministry of Education, International cooperation projects (Murdoch University) recently. My main research work is focusing on male reproductive health, molecular mechanism of spermatogenesis, beneficial gut microbiota improving spermatogenesis and increasing male fertility. The “Gut microbiota-testis” axis was confirmed with the correlation of intestinal microbes and male fertility. I have published more than 80 SCI articles (As the corresponding author, two articles in GUT/IF=31.793, one article in Microbiome/IF=14.65, two articles in Microbiology Spectrum/IF=9.043; As first author, one article in Theranostics/IF=11.556; one article in Mucosal Immunology/7.313). Eight patents have been authorized (6 of 8 first inventor), and four patents are the natural products to improve the semen quality and three patents are the beneficial microbes to increase semen quality. In 2019, I won the second prize of Shandong Provincial University Science and Technology Award (Ranking 1).

Grants:

 The National Natural Science Foundation of China (32070536): Mechanisms of muscarinic acetylcholine receptor M5 regulating testicular cell-cell junctions to control spermatogenesis, 2021.01-2024.12, In charge

 The National Natural Science Foundation of China (31772408): Transgenerational inheritance of NH3/H2S exposure on spermatogenesis and the underlying mechanisms，2018.01-2021.12, In charge

 National key research and development program projects of China：Health and nutrition regulation technology of gastrointestinal tract and reproductive tract in livestock and poultry, 2022.09-2026.08, Participate

Representative publications:

1. Cong Zhang, Bohui Xiong, Liang Chen, Wei Ge, Shen Yin, Yanni Feng, Zhongyi Sun, Qingyuan Sun, Yong Zhao*, Wei Shen*, Hongfu Zhang*. (2021). Rescue of male fertility following fecal microbiota transplantation from alginate oligosaccharide dosed mice. Gut 70(11), 2213-2215. IF2021=31.793

2. Pengfei Zhang, Yanni Feng, Lan Li, Wei Ge, Shuai Yu, Yanan Hao, Wei Shen, Xiao Han, Dongxue Ma, Shen Yin, Yu Tian, Lingjiang Min, Zhongyi Sun, Qingyuan Sun, Hongfu Zhang*, Yong Zhao*. (2021). Improvement in sperm quality and spermatogenesis following fecal microbiota transplantation from alginate oligosaccharide dosed mice. Gut 70(1), 222-225. IF2021=31.793

3. Pengfei Zhang, Jing Liu, Bohui Xiong, Cong Zhang, Beining Kang, Yishan Gao, Zengkuan Li, Wei Ge, Shunfeng Cheng, Yanan Hao, Wei Shen, Shuai Yu, Liang Chen, Xiangfang Tang, Yong Zhao*, Hongfu Zhang*. (2020). Microbiota from alginate oligosaccharide dosed mice successfully mitigated small intestinal mucositis. Microbiome 8(1), 112. IF2020=14.652

4. Yanan Hao, Yanni Feng, Xiaowei Yan, Liang Chen, Xiangping Ma, Xiangfang Tang, Ruqing Zhong, Zhongyi Sun, Manjree Agarwal, Hongfu Zhang*, Yong Zhao*. (2022). Gut microbiota-testis axis: FMT mitigates high-fat diet-diminished male fertility via improving systemic and testicular metabolome. Microbiology Spectrum 10, e0002822. IF2022=9.043

5. Xiaowei Yan, Yanni Feng, Yanan Hao, Ruqing Zhong, Yue Jiang, Xiangfang Tang, Dongxin Lu, Hanhan Fang, Manjree Agarwal, Liang Chen*, Yong Zhao*, Hongfu Zhang*. (2022). Gut-testis axis: microbiota prime metabolome to increase sperm quality in young type 2 diabetes. Microbiology Spectrum 10(5), e0142322. IF2022=9.043

6. Qingshi Meng, Liang Chen, Bohui Xiong, Beining Kang, Pengfei Zhang, Shanlong Tang, Hui Han, Wei Shen, Xiaohui Feng, Shengnan Feng, Ruqing Zhong, Xiangfang Tang, Sheng Zhang, Hongfu Zhang*, Yong Zhao*. (2021). Single-cell transcriptome sequencing and proteomics reveal neonatal ileum dynamic developmental potentials. mSystems 6, e0072521. IF2021=7.324

7. Yanan Hao, Yanni Feng, Xiaowei Yan, Liang Chen, Ruqing Zhong, Xiangfang Tang, Wei Shen, Qingyuan Sun, Zhongyi Sun, Yonglin Ren, Hongfu Zhang*, Yong Zhao*. (2022). Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes. Molecular Medicine 28(1), 45. IF2022=6.382

8. Bohui Xiong, Yue Jiang, Yandi Wang, Xiao Han, Cong Zhang, Ruqing Zhong, Wei Ge, Baoquan Han, Zhaojia Ge, Gui’an Huang, Shen Yin, Wei Shen, Qingyuang Sun, Zhongyi Sun, Yong Zhao*, Hongfu Zhang*. (2022). LncRNA8276 primes cell-cell adhesion for regulation of spermatogenesis. Andrology 10(8), 1687-1701. IF2022=4.456

9. Xiaowei Yan, Xiangping Ma, Yanan Hao, Jing Liu, Hanhan Fang, Dongxin Lu, Wei Shen, Hongfu Zhang, Wei Ge*, Yong Zhao*. (2022). Alginate oligosaccharides ameliorate busulfan-induced renal tubule injury. Journal of Functional Foods 92, 105048. IF2022=5.223

10. Hanhan Fang, Xiaohui Feng, Tao Xu, Ruqing Zhong, Dongxin Lu, Hongfu Zhang, Wei Shen, Yong Zhao*, Liang Chen*, Junjie Wang*. (2022). Gut-spleen axis: microbiota via vascular and immune pathways improve busulfan-induced spleen disruption. mSphere e0058122. IF2022=5.029