Name: Xiaowen Yang

Title: Researcher

Discipline: Preventive veterinary medicine

Research Interests: Prevention and control of brucellosis, antibiotic resistance and pathogenic mechanism of Brucella spp.

Tel: 010-62879251

E-mail: yangxiaowen01@caas.cn

1. Biography

1.1 Education Background

2007.9-2011.6, Southwest University, Bachelor Degree

2011.9-2014.6, Northwest A&F University, Master Degree

2014.9-2018.6 China Agricultural University, Doctoral Degree

1.2 Work Experience

2018.9-2021.7 National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Assistant researcher

2021.7-2022.8 National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Associate researcher

2022.9-present Institute of Animal Science, Chinese Academy of Agricultural Sciences, Researcher

2. Research activities

Mainly focus on the research of the prevention and control of brucellosis, especially the research of antibiotic resistance and pathogenic mechanism of brucellosis, exploiting molecular biological operation and bioinformatical tools. In recent years, some progress has been made in the research on the prevalence and traceability of Brucella spp., the sensitivity monitoring and drug resistance mechanism of common brucellosis clinical treatment drugs, and new brucellosis vaccines. In the past five years, she has published 16 SCI papers, including 8 papers as the first author; published 4 Chinese articles as the first author; applied for 2 national invention patents as the first author, and obtained one patent(CN113186308B); published one popular science work item.

3. Research Projects

1. National Natural Science Foundation of China, 81902105, Screening of rifampicin-resistant related genes and mechanism of dominant Brucella melitensis strains in China, Project leader;

2. Beijing Municipal Natural Science Foundation, 7222120, Study on the resistance mechanism of compound trimethoprim of Chinese Brucella melitensis isolates, 2022/01-2024/12, Project leader；

3. the State Key Laboratory of Infectious Disease Prevention and Control, China CDC, 2021SKLID508, Construction of live attenuated Brucella vaccine with limited generation proliferation regulated by operon, 2021/07-2024/06, Project leader;

4. Central Public-interest Scientific Institution Basal Research Fund, 2020-YWF-ZYSQ-09, Phenotypic changes and mechanisms of Brucella spp. under antibiotic selection, 2023/01-2024/12, Project leader.

4. Publications and Patents etc.

4.1 Publications

1. Yang XW, WangYZ, Li JQ, Chen JJ, Piao DR, Tian GZ, Zhao HY, Fan Y, Liu JY, Jiang H. Genetic characteristics of an amikacin-resistant Brucella abortus strains isolated from Marmota Himalayana. Microbial Pathogenesis 2022 Jan 15;164:105402.

2. Yang XW, Wu TL, Liu WX, Tian GZ, Zhao HY, Piao DR, Jiang H, Wu QM. Cell membrane components of Brucella melitensis play important roles in the resistance of low-level rifampicin. PLoS Negl Trop Dis. 2020 Dec 29;14(12):e0008888.

3. Yang XW, Piao DR, Mao LL, Pang B, Zhao HY, Tian GZ, Jiang H, Kan B. Whole-genome sequencing of rough Brucella melitensis in China provides insights into its genetic features. Emerg Microbes Infect. 2020 Dec;9(1):2147-2156.

4. Yang XW, Wang N, Cao XF, Bie PF, Xing ZF, Yin SH, Jiang H, Wu QM. First isolation and characterization of Brucella suis from yak. Genome. 2020 Aug;63(8):397-405.

5. Yang XW, Wang JW, Feng ZY, Zhang XJ, Wang XG, Wu QM. Relation of the pdxB-usg-truA-dedA Operon and the truA Gene to the Intracellular Survival of Salmonella enterica Serovar Typhimurium. Int J Mol Sci. 2019 Jan 17;20(2):380.

6. Yang XW, Wang JW, Bing GX, Bie PF, De YY, Lyu YL, Wu QM. Ortholog-based screening and identification of genes related to intracellular survival. Gene 2018, 651:134-142.

7. Yang XW, Yan H, Wang N, Li YX, Bie PF, Zang J, Li YJ, Lu YL, Wu QM. Whole-Genome Sequencing of Brucella melitensis from Xinjiang Provides Insights into its Genetic Features. Pak Vet J 2017, 37(3):251-256.

8. Yang XW, Li Y, Zang J, Li Y, Bie P, Lu Y, Wu Q. Analysis of pan-genome to identify the core genes and essential genes of Brucella spp. Mol Genet Genomics 2016, 291(2):905-912.

4.2 Patents

The invention relates to a RT - PCR kit for detecting Amikacin resistance of brucella and a method for using the kit. CN113186308B. (First completed author)

(Updated by 06-19-2023)