Personal Information

Mingxing Chu

Ph.D / Professor

Institute of Animal Science (IAS)

Chinese Academy of Agricultural Sciences (CAAS)

Address: No.2, Yuanmingyuan West Rd., Beijing 100193, China

Major: Animal Genetics and Breeding

Birth Date: Feb 23, 1968

Positional Titles

Chief scientist, mutton sheep and goat genetics and breeding team, Science and Technology Innovation Project of China.

Post scientist of breeding technologies and methods of mutton sheep and goats, China Agriculture Research System.

Expert of the high-level talent pool, China Association for Science and Technology.

Standing member of the council, Sheep and Goat Raising branch, Chinese Association of Animal Science and Veterinary Medicine (CAAV).

Member of the council, Animal Genetics and Breeding branch, CAAV.

Education Background

Mingxing Chu received his BSc degree in Animal Genetics & Breeding (1990) from Beijing Agricultural University, Beijing, China, his MS degree in Animal Genetics & Breeding (1993) from Beijing Agricultural University, Beijing, China and his Ph.D. in Animal Genetics & Breeding (1996) from China Agricultural University, Beijing, China.

Research Area

Professor Chu was engaged in basic research, technology innovation and talent training on animal genetics and breeding. His research focuses on the genetic mechanism controlling year-round estrus and high prolificacy in Chinese indigenous sheep and goat breeds. His team aims to identify vital molecular genetic markers assisting animal breeding, they have characterized variations of more than 50 genes in the hypothalamic-pituitary-gonadal axis, which were associated with litter size in sheep and goat. His team had established the methods to detect the high prolificacy major mutation FecB in sheep. He has been in charge of establishing “Molecular Detection Methods for High Prolificacy Major Gene FecB in Sheep - The People’s Republic of China Agricultural Industry Standard - NY/T 1672-2008”, which had been popularized and applied by more than 30 scientific institutes in China. He presided over 28 scientific research projects and participated in 30 projects at national, provincial, and ministerial levels. More than 700 academic papers from 1991 to 2023 (over 180 papers in SCI journals) have been published, and the 20 invention patents (ranked first) have been authorized.

Ongoing Research Projects

(1) Science and Technology Major Project of Inner Mongolia Autonomous Region of China (NMKJXM202203-2, Aug 2022 - Dec 2024) “Lambing performance evaluating and selecting of Huameng mutton sheep”.

(2) National Natural Science Foundation of China (32172704, Jan 2022 - Dec 2025) “The molecular mechanism of sheep seasonal estrus regulated by TSHR gene mutations”.

(3) Science and Technology Major Project of Inner Mongolia Autonomous Region of China (Nov 2020 - Nov 2022) “Gene identification card developing and hyper-prolificacy new line breeding of Bamei mutton sheep”.

(4) National Natural Science Foundation of China (31772580, Jan 2018 - Dec 2021) “The molecular mechanism of Booroola fecundity gene (FecB) affecting high prolificacy of Small Tail Han sheep revealed by single-cell RNA sequencing”.

(5) National Natural Science Foundation of China (31472078, Jan 2015 - Dec 2018) “Functional analysis of candidate genes, miRNAs and lncRNAs for ovine year-round estrus based on transcriptome sequencing”.

(6) Agricultural Science and Technology Innovation Project of China (ASTIP-IAS13, Jan 2014 - Dec 2025) “Mutton sheep and goat genetics and breeding”.

(7) Science and Technology Major Project of Inner Mongolia Autonomous Region of China (Jan 2014 - Dec 2016) “Reproductive performance improvement and optimization of crosses of mutton sheep in BayanNur”.

(8) National Natural Science Foundation of China-Xinjiang Joint Fund (U1130302, Jan 2012 - Dec 2015) “Molecular mechanism of cold resistance of Altay sheep in Xinjiang extremely cold regions”.

(9) Genetically Modified Organisms Breeding Major Program of China (2008ZX08012005, 2011ZX08010006, 2013ZX08010006, 2014ZX08010005, 2016ZX08010005, Jul 2008 - Dec 2020) “Evaluation of the breeding value of genetically modified animals with high prolificacy”.

(10) The Earmarked Fund for China Agriculture Research System (CARS-38)（Jan 2008 - Dec 2025）“breeding technologies and methods”.

Awards

(1) The special prize of Yunnan Science and Technology Progress Award, Ranked eighth, 2023, “The new breed cultivation and industrialization demonstration of Yunshang Black goat”.

(2) The first prize of the Xinjiang Production and Construction Corps Natural Science Award, Ranked fourth, 2022, “Genetic mechanisms of the formation of major economic traits in Xinjiang local sheep breeds”.

(3) The second prize of the Tianjin Science and Technology Progress Award, Ranked second, 2022, “Precise uncovering of high fecundity traits and the integrated application of supporting technologies for industrialization in meat sheep”.

(4) China High-level Talents Special Support Plan Scientific and Technological Innovation Leading Talent by Organization Department of the Central Committee of the Communist Party of China in 2016.

(5) National Leading Talent for Science and Technology Innovation by the Ministry of Science and Technology of China in 2014.

(6) The Science and Technology Achievement Award of Changxin Wu Animal Genetics and Breeding, Ranked first, 2013, “Screening and application of molecular genetic markers involved in reproductive traits of sheep and goat”.

(7) The third prize of the Beijing Science and Technology Award, Ranked first, 2013, “Screening and application of molecular genetic markers involved in reproductive traits of sheep and goat”.

(8) The second prize of the Hebei Science and Technology Progress Award, Ranked fourth, 2011, “Establishment and demonstration of the well-bred breeding system of high producing dairy cattle in North China plain”.

(9) Special Government Allowance by State Council of China, 2011.

(10) Mao Yisheng Beijing Youth Science and Technology Award by Beijing Association for Science and Technology, 2008.

(11) National Scientist of the New Century Hundred, Thousand and Ten Thousand Talent Project of China in 2008.

(12) The 10th Youth Science and Technology Award by China Association of Agricultural Science Societies, 2007.

(13) The second prize of the Beijing Science and Technology Award, Ranked first, 2004, “Genetic research and utilization of germplasm resources in Small Tail Han sheep”.

(14) The second prize of the National Science and Technology Progress Award of China, Ranked fifth, 2001, “Theories and technologies of livestock genetic resources conservation”.

(15) The first prize of the Science and Technology Progress Award by China Ministry of Agriculture, Ranked fifth, 1999, “Theories and technologies of livestock genetic resources conservation”.

Books

1. Mingxing Chu, Shoukun Shi. Type Linear Appraisal and Application in Dairy Cattle. China Agricultural Science and Technology Press. Beijing, Aug 1999.

2. Mingxing Chu, Changxin Wu, Jiansheng Zhang. Research and Application of High Fertility in Taihu Pig. China Agricultural Science and Technology Press. Beijing, Sep 2003.

3. Mingxing Chu translation. Introduction to Quantitative Genetics (Fourth Edition), China Agricultural Science and Technology Press. Beijing, May 2000.

Representative Papers

(1) Liu Y F#, Liu Z Y#, Li W T, Wang P, Wang X Y, Di R, He X Y, Chu M X*. Effect of melatonin on ATG2B-mediated autophagy regulation in sheep granulosa cells with different FecB genotypes. Journal of Pineal Research, 2023, e12890.

(2) Liu S Q, Liu Z Y, Wang P, Li W T, Zhao S G, Liu Y F*, Chu M X*. Estrogen-mediated oar-miR-485-5p targets PPP1R13B to regulate myoblast proliferation in sheep. International Journal of Biological Macromolecules, 2023, 236:123987.

(3) Wang P, Li W T, Liu Z Y, He X Y, Hong Q H, Lan R, Liu Y F*, Chu M X*. Identification of WNT4 alternative splicing patterns and effects on proliferation of granulosa cells in goat. International Journal of Biological Macromolecules, 2022, 223:1230-1242.

(4) Hu W P, Dong X L, Tian Z L, Zhang Z B, Tang J S, Liang B M, Liu Q Y*, Chu M X*. Expression, structure and function analysis of the sperm-oocyte fusion genes Juno and Izumo1 in sheep (Ovis aries). Journal of Animal Science and Biotechnology, 2021, 12(1):37.

(5) Chen S#, Guo X F#, He X Y, Di R, Zhang X S, Zhang J L, Wang X Y*, Chu M X*. Insight into pituitary lncRNA and mRNA at two estrous stages in Small Tail Han sheep with different FecB genotypes. Frontiers in Endocrinology, 2022, 12:789564.

(6) Sun Z P, Hong Q H, Liu Y F, He X Y, Di R, Wang X Y, Ren C H, Zhang Z J*, Chu M X*. Characterization of circular RNA profiles of oviduct reveal the potential mechanism in prolificacy trait of goat in the estrus cycle. Frontiers in Physiology, 2022, 13:990691.

(7) Li W T#, Li K Y#, He X Y, Jiang Y T, Lan R, Hong Q H, Liu Y F*, Chu M X*. ALAS1 associated with goat kidding number trait was regulated by the transcription factor ASCL2 to affect granulosa cell proliferation. Animal Genetics, 2023, 54(2):189-198.

(8) Guo X F#, Wang X Y#, Di R, Liu Q Y, Hu W P, He X Y, Yu J R, Zhang X S, Zhang J L, Broniowska K, Chen W, Wu C X*, Chu M X*. Metabolic effects of FecB gene on follicular fluid and ovarian vein serum in sheep (Ovis aries). International Journal of Molecular Sciences, 2018, 19(2):539.

(9) Chen S#, Guo X F#, He X Y, Di R, Zhang X S, Zhang J L, Wang X Y*, Chu M X*. Transcriptome analysis reveals differentially expressed genes and long non-coding RNAs associated with fecundity in sheep hypothalamus with different FecB genotypes. Frontiers in Cell and Developmental Biology, 2021, 9:633747.

(10) Sun Z P, Liu Y F, He X Y, Di R, Wang X Y, Ren C H, Zhang Z J*, Chu M X*. Integrative proteomics and transcriptomics profiles of the oviduct reveal the prolificacy-related candidate biomarkers of goats (Capra hircus) in estrous periods. International Journal of Molecular Sciences, 2022, 23:14888.

Contact Ways

Tel: +86-10-62819850, 13681285159

Fax: +86-10-62895351

E-mail: chumingxing@caas.cn, mxchu@263.net

    Website: https://ias.caas.cn