Personal Information

Yulian Mu, Ph.D., Professor, Doctoral supervisor. Professor Mu received her B.S. degree from Hebei Agricultural University in 1999, M.S. degree from Hebei Agricultural University in 2002, and Ph.D. degree from Chinese Academy of Agricultural Sciences in 2009. Professor Mu has been working at the Institute of Animal Science, Chinese Academy of Agricultural Sciences since 2002. Professor Mu is the backbone expert of pig genetic engineering and germplasm innovation team and the group leader of Pig Genetic Engineering and Material Innovation Group now. She is also one of the executive directors of the 10th Council of the Animal Reproduction Branch of the Chinese Association of Animal Science and Veterinary Medicine.

Research Direction and Achievements

Professor Mu has been devoted to the research of gene-editing technology of pigs, pig breeding material creation and breeding of Wuzhishan mini-pig inbred line, etc. She has published more than 40 SCI papers in journals like Trends in Biotechnology, National Science Review, Science China-Life Sciences, eLife, Redox Biology etc. She also has participated in the formulation of 4 national, local and/or industry standards; granted 14 national invention patents and 1 utility model patent, 2 US invention patents. She has received 7 awards including the First Prize of Chinese Agricultural Science and Technology, the Second Prize of Hainan Science and Technology, and the Second Prize of Beijing Science and Technology etc.

Projects in Research

1. National Natural Science Foundation of China General Program (Principal Investigator, No. 32072690)

2. National Natural Science Foundation of China Key Program (Backbone expert, No. 32130102)

Representative papers and patents

Patents：

1. A pair of sgRNAs specifically recognizing the porcine Wip1 gene and their applications and products (ZL201911323387.3)

2. A method of targeted mutation of LDLR gene (ZL201610753031.3)

3. A method of targeted mutation of ApoE gene (ZL201610755598.4)

Papers：

1. Fan Z(#), Mu Y(#), Sonstegard T, Zhai X, Li K(*), Hackett PB(*), Zhu Z. Social acceptance for commercialization of genetically modified food animals. Natl Sci Rev. 2021 Apr 21;8(8):nwab067. doi: 10.1093/nsr/nwab067.

2. Fan Z(#), Mu Y(#), Li K(*), Hackett PB(*). Safety evaluation of transgenic and genome-edited food animals. Trends Biotechnol. 2022 Apr;40(4):371-373. doi: 10.1016/j.tibtech.2021.10.012.

3. Xu K(#), Zhang X(#), Liu Z(#), Ruan J, Xu C, Che J, Fan Z, Mu Y(*), Li K(*). A transgene-free method for rapid and efficient generation of precisely edited pigs without monoclonal selection. Sci China Life Sci. 2022 Aug;65(8):1535-1546. doi: 10.1007/s11427-021-2058-2.

4. Fan Z(#), Liu Z(#), Xu K(#), Wu T, Ruan J, Zheng X, Bao S, Mu Y(*), Sonstegard T(*), Li K(*). Long-term, multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production. Sci China Life Sci. 2022 Feb;65(2):362-375. doi: 10.1007/s11427-020-1927-9.

5. Xu K(#), Zhou Y(#), Mu Y(#)(*), Liu Z, Hou S, Xiong Y, Fang L, Ge C, Wei Y, Zhang X, Xu C, Che J, Fan Z, Xiang G, Guo J, Shang H, Li H, Xiao S(*), Li J(*), Li K(*). CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance. elife. 2020 Sep 2;9:e57132. doi: 10.7554/eLife.57132.

6.Xu SS(#), Zhang XL(#), Liu SS(#), Feng ST, Xiang GM, Xu CJ, Fan ZY, Xu K, Wang N, Wang Y, Che JJ, Liu ZG, Mu YL(*), Li K(*). Multi-Omic Analysis in a Metabolic Syndrome Porcine Model Implicates Arachidonic Acid Metabolism Disorder as a Risk Factor for Atherosclerosis. Front Nutr. 2022 Feb 23;9:807118. doi: 10.3389/fnut.2022.807118.

7.Yiting Tang(#), Bing Pan(#), Xin Zhou(#), Kai Xiong, Qian Gao, Lei Huang, Ying Xia, Ming Shen, Shulin Yang, Honglin Liu, Tao Tan, Jianjie Ma, Xuehong Xu, Yulian Mu(*),Kui Li(*). Wip1-dependent modulation of macrophage migration and phagocytosis, Redox Biology, 2017, 13: 665-673.

8.LIU Yang, GAO Qian, ZHANG Xue, HUANG Lei, XU Kui, HU Yan-qing, LIU Lan, MU Yu-lian(*), LI Kui. PNPLA5-knockout rats induced by CRISPR/Cas9 exhibit abnormal bleeding and lipid level. Journal of Integrative Agriculture, 2017, 16(1): 169-180.

9. Huang L, Niu C, Willard B, Zhao W, Liu L, He W, Wu T, Yang S, Feng S, Mu Y(*), Zheng L(*), Li K(*).Proteomic analysis of porcine mesenchymal stem cells derived from bone marrow and umbilical cord: implication of the proteins involved in the higher migration capability of bone marrow mesenchymal stem cells. Stem Cell Research & Therapy, 2015, 6(1):77.

10. YitingTang, LanLiu, MingSheng, KaiXiong, LeiHuang, QianGao, Jingliang Wei, TianwenWu, ShulinYang, HonglinLiu(*), YulianMu(*), KuiLi. Wip1 knockout inhibits the proliferation and enhances the migration of bone marrow mesenchymal stem cells. Experimental Cell Research, 2015, 334:310-322.

11. Xiaodong Fang(#), Yulian Mu(#), Zhiyong Huang(#), Yong Li(#), Lijuan Han, Yanfeng Zhang, Yue Feng,Yuanxin Chen, Xuanting Jiang, Wei Zhao, Xiaoqing Sun, Zhiqiang Xiong, Lan Yang, Huan Liu,Dingding Fan, Likai Mao, Lijie Ren, Chuxin Liu, Juan Wang, Kui Li, Guangbiao Wang, Shulin Yang,Liangxue Lai, Guojie Zhang, Yingrui Li, Jun Wang, Lars Bolund, Huanming Yang, Jian Wang,Shutang Feng(*), Songgang Li(*), Yutao Du(*). The sequence and analysis of a Chinese pig genome. Gigascience, 2012,1:16.

Contacts

E-mail: mouyulian@caas.cn