Jian Tian , male, born in Shijiazhuang, Hebei Province, is a professor and doctoral supervisor. His main research area is agricultural protein intelligent design. He has published over 70 SCI papers, 41 of which were published as the first or corresponding author. He has also obtained 20 invention patents (9 of which he was the first author) and 13 software copyrights. In 2022, his team won the gold medal in the regional competition and silver medal in the national competition of the Shengteng AI Innovation Competition. Additionally, he was awarded the 4th Fan Yunliu Academician Youth Science and Technology Innovation Award.
Publications
Ding, Zundan#, Xu, Guoshun#, Miao, Ruiju, Wu, Ningfeng, Zhang, Wei, Yao, Bin, Guan, Feifei, Huang, Huoqing*, Tian, Jian*, 2023. Rational redesign of thermophilic PET hydrolase LCCICCG to enhance hydrolysis of high crystallinity polyethylene terephthalates. J Hazard Mater 453, 131386. https://doi.org/10.1016/j.jhazmat.2023.131386.
Zhang, Yan#, Guan, Feifei#, Xu, Guoshun, Liu, Xiaoqing, Zhang, Yuhong, Sun, Jilu, Yao, Bin, Huang, Huoqing*, Wu, Ningfeng, Tian, Jian*, 2022. A novel thermophilic chitinase directly mined from the marine metagenome using the deep learning tool Preoptem. Bioresources and Bioprocessing 9(1). https://doi.org/10.1186/s40643-022-00543-1.
Ding, Zundan#, Guan, Feifei#, Xu, Guoshun, Wang, Yuchen, Yan, Yaru, Zhang, Wei, Wu, Ningfeng, Yao, Bin, Huang, Huoqing Huang*, Tuller, Tamir*, Tian, Jian*. MPEPE, a predictive approach to improve protein expression in E. coli based on deep learning. Computational and Structural Biotechnology Journal. 2022 Vol. 20 Pages 1142-1153.
Wang Yifan#, Zhang Pingxian#, Guo Weijun#, Liu Hanqing#, Zhang Qian, Han Xiao, Pu Li*, Tian, Jian*, Gu Xiaofeng*. A deep learning approach to automate whole-genome prediction of diverse epigenomic modifications in plants. New Phytol. 2021 Oct;232(2):880-897.
Meng, Xiangxi#, Yang, Lixin#, Liu, Hanqing#, Li, Qingbin, Xu, Guoshun, Zhang, Yan, Guan, Feifei, Zhang, Yuhong, Zhang, Wei, Wu, Ningfeng*, Tian, Jian*. Protein engineering of stable IsPETase for PET plastic degradation by Premuse. Int J Biol Macromol. 2021 Jun 1;180:667-676.
Guan, Feifei#; Han, Yanshuo#; Yan, Kai; Zhang, Yan; Zhang, Zhifang; Wu, Ningfeng*; Tian, Jian*; Highly efficient production of chitooligosaccharides by enzymes mined directly from the marine metagenome., Carbohydrate Polymers, 2020, 234: 115909.
Zhang, Pingxian, Wang, Yifan, Chachar, Sadaruddin, Tian, Jian* and Gu, Xiaofeng* (2020) eRice: a refined epigenomic platform for japonica and indica rice. Plant biotechnology journal, 18, 1642-1644.
Tian, Jian#，Woodard, Jaie#，Whitney, Anna，Shakhnovich, Eugene(*)，Thermal Stabilization of Dihydrofolate Reductaseusing Monte Carlo Unfolding Simulations and its Functional Consequences，PLoS Computational Biology, 2015, 2015, 11(4):e1004207.
Tian, Jian, Wang, Ping, Gao, Shan, Chu, Xiaoyu, Wu, Ningfeng*, Fan, Yunliu: Enhanced thermostability of methyl parathion hydrolase from Ochrobactrum sp. M231 by rationally engineering a glycine to proline mutation. FEBS Journal 2010, 277:4901-4908.
Tian, Jian, Wu, Ningfeng*, Li, Jiang, Liu, Yajie, Guo, Jun, Yao, Bin*, Fan, Yunliu: Nickel-resistant determinant from Leptospirillum ferriphilum. Applied and environmental microbiology 2007, 73(7):2364-2368.