Personal information
Yanfang Wang, Ph.D.
Professor, Principal Investigator
Animal gene engineering and germplasm innovation group
Institute of Animal Science
Chinese Academy of Agricultural Sciences (CAAS)
Haidian District, Beijing, 100193
Phone: 15701243765 (Cell)
E-mail: wangyanfang@caas.cn
Education
1994.09-1998.06, B.S. Shanxi Agricultural University, Taigu, China
1998.09-2001.06, M.S. Gansu Agricultural University, Lanzhou, China
2001.09-2004.06, Ph.D. Huazhong Agricultural University, Wuhan, China
Professional Experience
2004.07 -2005.03, Postdoc, Biomedical Institute, Fudan University, Shanghai, China
2005.04 -2007.03, Postdoc, Iowa State University, Ames, IA, USA
2007.04 -2008.08, Postdoc, LSU Health Science Center, New Orleans, LA, USA
2008.09 -2011.12, Postdoc, Life Sciences Center, University of Missouri, Columbia, MO, USA
2012.01 -2014.01, Research Assistant Professor, Life Sciences Center, University of Missouri, Columbia, MO, USA
2014.02-present, Professor, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing, China
Academic association member
Standing Committee of Comparative and Functional Genomics Workshop, International Society of Animal Genetics (ISAG) (2014-2021)
Committee member of National Agricultural Genomics Association (2017-Present)
Research interest
Functional characterization of the porcine genome
Genome editing of pigs
Development of swine models for both agricultural and biomedical purposes
Selected Publications (*Corresponding Author)
(1) Pan J#, Chui L#, Liu T, Zheng Q, Liu X, Liu L, Zhao Y, Zhang L, Song M, Han J, Huang J, Tang C, Tao C, Zhao J*, Wang Y*. Fecal Microbiota Was Reshaped in UCP1 Knock-In Pigs via the Adipose-Liver-Gut Axis and Contributed to Less Fat Deposition. Microbiol Spectr. 2023 Feb 14;11(1):e0354022.
(2) Song R, Wang Y, Zheng Q, Yao J, Cao C, Wang Y*, Zhao J*. One-step base editing in multiple genes by direct embryo injection for pig trait improvement. Sci China Life Sci. 2022 Apr;65(4):739-752.
(3) Zhao Y#, Pan J#, Cao C, Liang X, Yang S, Liu L, Tao C, Zhao J, Wang Y*. RNF20 affects porcine adipocyte differentiation via regulation of mitotic clonal expansion. Cell Prolif. 2021 Oct 14:e13131.
(4) Yao J#, Wang Y#, Cao C#, Song R, Bi D, Zhang H, Li Y, Qin G, Hou N, Zhang N, Zhang J, Guo W, Yang S, Wang Y*, Zhao J*. CRISPR/Cas9-mediated correction of MITF homozygous point mutation in a Waardenburg syndrome 2A pig model. Mol Ther Nucleic Acids. 2021 Apr 16;24:986-999.
(5) Li F#, Wang D#, Song R#, Cao C#, Zhang Z#*, Wang Y, Li X, Huang J, Liu Q, Hou N, Xu B, Li X, Gao X, Jia Y, Zhao J, Wang Y*. The asynchronous establishment of chromatin 3D architecture between in vitro fertilized and uniparental preimplantation pig embryos. Genome Biol. 2020 Aug 10;21(1):203.
(6) Liang X#, Tao C#, Pan J, Zhang L, Liu L, Zhao Y, Fan Y, Cao C, Liu J, Zhang J, Lam SM, Shui G, Jin W, Li W, Zhao J*, Li K*, Wang Y*. Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis. Protein Cell. 2020 Aug 14.
(7) Tao C#, Wang Y#, Zhao Y, Pan J, Fan Y, Liang X, Cao C, Zhao J, Petris MJ, Li K, Wang Y*. Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy. Diabetologia. 2019 Aug 8.
(8) Pan J#, Tao C#, Cao C, Zheng Q, Lam SM, Shui G, Liu X, Li K, Zhao J, Wang Y*. Adipose lipidomics and RNA-Seq analysis revealed the enhanced mitochondrial function in UCP1 knock-in pigs. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1375-1383.
(9) Lin J#, Cao C#, Tao C#, Ye R, Dong M, Zheng Q, Wang C, Jiang X, Qin G, Yan C, Li K, Speakman J. R, Wang Y*, Jin W*, Zhao J*, Cold adaptation in pigs depends on UCP3 in beige adipocytes, Journal of Molecular Cell Biology, 2017, Oct 1,9(5): 364-375.
(10) Zheng Q#, Lin J#, Huang J#, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zhang N, Piao Z, Ye R, Speakman JR, Wang H, Zhou Q, Wang Y*, Jin W*, Zhao J*. Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity. Proc Natl Acad Sci U S A. 2017, Nov 7;114(45):E9474-E9482.