一、个人信息

徐欣欣，女，1986年1月生，山东泰安人，博士，研究员，博士生导师。

二、研究方向与成果

围绕国家粮食安全和饲用蛋白资源重大需求，致力于饲用资源的高值转化和生物合成研究，创建了基于合成生物技术和微生物细胞工厂的秸秆高值饲料化技术体系，实现将秸秆高效同步转化为饲料蛋白和人造淀粉。系统开展了丝状真菌细胞工厂的构建及应用，基于高效基因组编辑及菌株集成改造技术，实现多种酶蛋白在丝状真菌中的高水平表达分泌。

三、在研项目

1. “十四五”国家重点研发计划青年项目“高效利用秸秆合成微生物蛋白的菌种创制”

2. 国家自然科学基金面上项目“缓解动物氧化应激的过氧化氢酶高效表达机制研究”

3. 国家重点研发计划子课题“纤维素制淀粉酶元件的表达及晶体结构解析”

4. 中国农业科学院青年创新任务项目“单细胞蛋白合成菌株对秸秆抑制因子的耐受机制研究”

5.中国农科院基础科学研究中心任务“新型饲料营养蛋白的人工设计规律和高效生物合成调控机制” 

四、代表性论文和授权专利

1. 专利：裂解性多糖单加氧酶突变体RsLPMO9 M2及其制备方法和应用（ZL202510345213.6）

2. 专利：一种提高特异腐质霉中过氧化氢酶表达量的方法（20251196029323）

3. 漆酶作为催化剂在催化合成尿囊素中的用途（ZL202511045701.1）

4. α-葡聚糖磷酸化酶5CC5改良突变体（5CC5E535V）及其在淀粉合成中的应用（ZL202411700314.2）

5. 调控真菌木质纤维素降解酶系表达的元件及其应用（ZL202010708586.2）

6. 根瘤农杆菌介导的特异腐质霉的遗传转化方法及其表达载体（ZL 201610582793.1）

7. Xinxin Xu, Wei Zhang*, Chun You, Chao Fan, Wangli Ji, Jong-Tae Park, Jiyun Kwak, Hongge Chen, Yi-heng P. Job Zhang*, Yanhe Ma*. Biosynthesis of artificial starch and microbial protein from agricultural residue. Sci Bull, 2023, 68:214-223.

8. Yanjun Li, Guoshun Xu, Jian Tian, Wangli Ji, Bo Liu, Tao Tu, Yuan Wang,  Huoqing Huang, Huiying Luo, Bin Yao, Feifei Guan, Wei Zhang, Xinxin Xu*. Novel α-glucan phosphorylase coupled with thermotolerant yeast facilitated a high conversion rate from corn stover to artificialstarch and microbial protein, Chem Eng J, 2026, 527

9. Wangli Ji, Xiaolu Wang, Xiaoqing Liu, Yuan Wang, Fangui Liu, Bo Xu, Huiying Luo, Tao Tu, Wei Zhang, Xinxin Xu*, Xiaoyun Su*. Combining manipulation of integration loci and secretory pathway on expression of an Aspergillus niger glucose oxidase gene in Trichoderma reesei. Microb Cell Fact, 2023, 22:38.

10. Chao Fan, Wei Zhang, Xiaoyun Su, Wangli Ji, Huiying Luo, Yuhong Zhang, Bo Liu, Bin Yao, Huoqing Huang*, Xinxin Xu*. CRISPR/Cas9-mediated genome editing directed by a 5S rRNA–tRNAGly hybrid promoter in the thermophilic filamentous fungus Humicola insolens. Biotechnol Biofuels, 2021, 14(206).

11. Xinxin Xu, Chao Fan, Liya Song, Jinyang Li, Yuan Chen, Yuhong Zhang, Bo Liu, Wei Zhang. A Novel CreA-Mediated Regulation Mechanism of Cellulase Expression in the Thermophilic Fungus Humicola insolens. Int J Mol Sci, 2019, 20(15): 0-3693.

12. Xinxin Xu, Xiaohu Fan, Chao Fan, Xing Qin, Bo Liu, Chunming Nie, Ning Sun, Qingzhi Yao, Yuhong Zhang, Wei Zhang. Production Optimization of an Active β-Galactosidase of Bifidobacterium animalis in Heterologous Expression Systems. BioMed Res Int, 2019, 8010635.

13. Chengliang Yan^#, Xinxin Xu^#, Xue Zhang^#; Yuwei Zhang, Yuhong Zhang,.; Zhifang Zhang, Wei Zhang, Bo Liu. Decreased rhamnose metabolic flux improved production of target proteins and cell flocculation in Pichia pastoris. Front Microbiol, 2018, 9, 1771.

14. Xiaoyan Ning, Zhang, Y.; Yuan, T.; Li, Q.; Tian, J.; Guan, W.; Liu, B.; Zhang, W.; Xinxin Xu*; Yuhong Zhang*. Enhanced thermostability of glucose oxidase through computer-aided molecular design. Int J Mol Sci, 2018, 19 (2), 425.

15. Chao Fan^#, Xinxin Xu^#, Liya Song, Weishi Guan, Jinyang Li, Bo liu, Pengjun Shi, Wei Zhang. The use of Agrobacterium-mediated insertional mutagenesis sequencing to identify novel genes of Humicola insolens involved in cellulase production, 3 Biotech, 2018, 8:153.

16. Wei Xia^#, Xinxin Xu^#, Liqun Qian, Pengjun Shi, Yingguo Bai, Huiying Luo, Rui Ma, Bin Yao. Engineering a highly active thermophilic β-glucosidase to enhance its pH stability and saccharification performance, Biotechnol Biofuels, 2016, 9:147.

17. Xinxin Xu, Jinyang Li, Pengjun Shi, Wangli Ji, Bo Liu, Yuhong Zhang, Bin Yao, Yunliu Fan, Wei Zhang. The use of T-DNA insertional mutagenesis to improve cellulase production by the thermophilic fungus Humicola insolens Y1. Sci Rep, 2016, 6:31108-31108.

18. Xinxin Xu, Jinyang Li, Wei Zhang, Huoqing Huang, Pengjun Shi, Huiying Luo, Bo Liu, Yuhong Zhang, Zhifang Zhang, Yunliu Fan, Bin Yao. A Neutral Thermostable beta-1,4-Glucanase from Humicola insolens Y1 with Potential for Applications in Various Industries. PLoS One, 2015, 4.24,10 (4).

19. Jinyang Li^#, Xinxin Xu^#, Pengjun Shi, Bo Liu, Yuhong Zhang, Wei Zhang. Overexpression and characterization of a novel endo-β-1,3(4) -glucanase from thermophilic fungus Humicola insolens Y1，Protein Expr Purif，2015, 11.22.

20. Xinxin Xu, Ling Liu, Fan Zhang , et al., Identification of the first diphenyl ether gene cluster for pestheic acid biosynthesis in plant endophyte Pestalotiopsis fici. Chembiochem, 2014. 15(2):284-92.

21. Xinxin Xu, Jing Yang, Yang An , et al., Over-expression of pcvA involved in vesicle–vacuolar fusion affects the conidiation and penicillin production in Penicillium chrysogenum. Biotechnol Lett, 2012. 34, 519-526.

22. 徐欣欣，李彦君，张伟，黄火清，罗会颖，姚斌，人造淀粉生物合成技术：进展、挑战与展望，生物技术通报，2025. 11:22-27

23. 王瑾; 白静; 赵晶; 田健; 张伟; 王苑; 杨浩萌; 石美杉; 张贝贝; 徐欣欣*; 黄火清; 新型GH45家族纤维素酶的智能挖掘及在里氏木霉中的高效表达, 生物技术进展, 2025. 2:287-295

联系方式

E-mail: xuxinxin@caas.cn

（简历更新时间2026年10月30日）