一、个人信息

张伟，女，1973年11月生，河北石家庄人，博士，三级研究员，博士生导师。

二、研究方向与成果

长期从事微生物酶制剂的创制及开发利用，微生物智能细胞工厂的创建、秸秆高值转化等研究工作。主持和参加国家“十一五”“十二五”“863”、转基因重大专项、国家自然科学基金、农业科技成果转化、国家重点研发计划等课题二十余项。两项酶制剂高效生产技术成果实现产业化应用。

三、在研项目

1. 国家重点研发计划“纤维素制淀粉的酶元件挖掘与适配性改造”；

2. 中国农业科学院重大科技子任务“乡村废弃物预处理与副产物高值利用”。

四、代表性论文和授权专利

1. 专利：提高α-葡聚糖磷酸化酶的高温催化活性的方法及突变体TpαGPM1、基因和应用（ZL 202510961770.0）

2. 专利：黑曲霉葡萄糖氧化酶优化基因及其表达载体和应用（ZL201811304241.X）

3. 专利：β-galactosidase mutant with high transglycosidase activity, and preparation method thereof and use thereof（US 10,053,682 B2）

4. Yanjun Li , Guoshun Xu , Jian Tian , Wangli Ji , Bo Liu, Tao Tu, Yuan Wang , Huoqing Huang , Huiying Luo, Bin Yao , Feifei Guan* , Wei Zhang* , Xinxin Xu*, Novel α-glucan phosphorylase coupled with thermotolerant yeast facilitated a high conversion rate from corn stover to artificial starch and microbial protein, Chemical Engineering Journal, 2025, 527.172048.

5.  Xiaoyun Su* , Shuai Wang , Xiaolu Wang , Wangli Ji , Honglian Zhang, Tao Tu , Nina Hakulinen, Huiying Luo, Bin Yao, Wei Zhang*, Huoqing Huang*, Targeting deoxynivalenol for degradation by a chimeric manganese peroxidase/ glutat hione system, Ecotoxicol Environ Saf ., 2024, 15:273:116130.

6. Wangli Ji , Li Xu , Xianhua Sun, Xinxin Xu, Honglian Zhang, Huiying Luo, Bin Yao,Wei Zhang*, Xiaoyun Su*, Huoqing Huang*, Exploiting Systematic Engineering of the Expression Cassette as a Powerful Tool to Enhance Heterologous Gene Expression in Trichoderma reesei, J Agric Food Chem., 2024, 13;72(10):5307- 5317 . 

7.Xinxin Xu, Wei Zhang*, Chun You, Chao Fan, Wangli Ji, Jong-Tae Park, Jiyun Kwak, Hongge Chen, Yi-heng P. Job Zhang*, Yanhe Ma*, Biosynthesis of artificial starch and microbial protein from agricultural residue, Sci Bull, 2023, 68:214-223.

8. Wang S, Wang X, Penttinen L, Luo H, Zhang Y, Liu B, Yao B, Hakulinen N, Zhang W*, Su X*, Patulin Detoxification by Recombinant Manganese Peroxidase from Moniliophthora roreri Expressed by Pichia pastoris, Toxins (Basel), 2022, 29;14(7): 440.

9. Chao Fan^# , Wei Zhang^# , Xiaoyun Su , Wangli Ji , Huiying Luo , Yuhong Zhang, Bo Liu, Bin Yao , Huoqing Huang* , Xinxin Xu*, CRISPR/Cas9-mediated genome editing directed by a 5S rRNA-tRNAGly hybrid promoter in the thermophilic filamentous fungus Humicola insolens, Biotechnol Biofuels, 2021, 14: 206.

10. Yaru Yan, Weishi Guan, Xiaoyi Li, Kaier Gao, Xinxin Xu, Bo Liu, Wei Zhang*, Yuhong Zhang*, β-galactosidase GALA from Bacillus circulans with high transgalactosylation activity, Bioengineered, 2021, 12(1): 8908-8919.

联系方式

E-mail: zhangwei02@caas.cn

（简历更新时间为2026年11月2日）