个人信息

田健，1979年4月生，河北省新乐人，博士，研究员，博士生导师。2003年获河北农业大学学士学位；2006年获中国农业科学院硕士学位；2011年获中国农业科学院博士学位；2013年-2014年在美国哈佛大学从事博士后研究。2023年至今在中国农业科学院北京畜牧兽医研究所工作。主要从事蛋白智能分子设计研究，现任微生物与酶工程创新团队骨干专家；中国生物信息学会（筹）农林专业委员会委员。荣获昇腾AI创新大赛区域赛金奖和全国赛银奖，获第四届范云六院士青年科技创新奖。

    研究方向与成果

2006年以来，主要从事蛋白智能分子设计研究工作，致力于构建人工智能与酶蛋白相结合的蛋白智能分子设计平台，提高酶蛋白的稳定性、表达量、催化活性等应用性能，提升其产业价值。

    在研项目：

1. 国家自然科学基金重大项目“节粮高效智能化育种技术体系建立与应用”（编号：32494804）

2. “十四五”国家重点研发计划政府间国际科技创新合作重点专项项目负责人（编号：2022YFE0135300）

3. “十四五”国家重点研发计划“造纸酶制剂的智造与产业化”课题负责人（编号：2022YFC2105501）

    代表性论文

    1.Tuoyu Liu, Yiyang Zhang, Yanjun Li, Guoshun Xu, Han Gao, Pengtao Wang, Tao Tu, Huiying Luo, Ningfeng Wu, Bin Yao, Bo Liu*, Feifei Guan*, Huoqing Huang*, Jian Tian*(Corresponding author). Effective gene expression prediction and optimization from protein sequences. Advanced Science. 2025. DOI: 10.1002/advs.202407664.

    2.Li, Lijian#, Tian, Jian#, Huang, K., Xue, X., Chen, J., Guan, F., Zhang, T., Sun, Y., He, C., Zeng, Xibai, Su, Shiming*. Metal-Binding Protein TaGlo1 Improves Fungal Resistance to Arsenite (As(III)) and Methylarsenite (MAs(III)) in Paddy Soil. Environ Sci Technol. 2024. 58(17):7469-7479

    3.Miao, Ruiju, Xu, Guoshun, Ding, Yekun, Ding, Zundan, Woodard, J., Tu, Tao, Luo, Huiying., Wu, Ningfeng, Yao, Bin, Guan, Feifei*, Tian, Jian*(Corresponding author). Engineering dual-functional and thermophilic BMHETase for efficient degradation of polyethylene terephthalate. Bioresour Technol 2024. 414:131556.

    4.Liu, Hanqing#, Guan, Feifei#, Liu, Tuoyu#, Yang, Lixin#, Fan, Lingxi, Liu, Xiaoqing, Luo, Huiying, Wu, Ningfeng, Yao, Bin, Tian, Jian*(Corresponding author), Huang, Huoqing*: MECE: a method for enhancing the catalytic efficiency of glycoside hydrolase based on deep neural networks and molecular evolution. Science Bulletin 2023, 68:2793-2805

    5.Liu, Tuoyu, Gao, Han, Ren, Xiaopu, Xu, Guoshun, Liu, Bo, Wu, Ningfeng, Luo, Huiying, Wang, Yuan, Tu Tao, Yao, Bin, Huang, Huoqing*, Tian, Jian*(Corresponding author): Protein-protein interaction and site prediction using transfer learning. Brief Bioinform 2023, 24(6).

    6.Ding, Zundan#, Xu, Guoshun#, Miao, Ruiju, Wu, Ningfeng, Zhang, Wei, Yao, Bin, Guan, Feifei, Huang, Huoqing*, Tian, Jian*, 2023. Rational redesign of thermophilic PET hydrolase LCCICCG to enhance hydrolysis of high crystallinity polyethylene terephthalates. J Hazard Mater 453, 131386. https://doi.org/10.1016/j.jhazmat.2023.131386.

    7.Meng, Xiangxi#, Yang, Lixin#, Liu, Hanqing#, Li, Qingbin, Xu, Guoshun, Zhang, Yan, Guan, Feifei, Zhang, Yuhong, Zhang, Wei, Wu, Ningfeng*, Tian, Jian*(Corresponding author). Protein engineering of stable IsPETase for PET plastic degradation by Premuse. Int J Biol Macromol. 2021 Jun 1;180:667-676.

    8.Guan, Feifei#; Han, Yanshuo#; Yan, Kai; Zhang, Yan; Zhang, Zhifang; Wu, Ningfeng*; Tian, Jian*(Corresponding author); Highly efficient production of chitooligosaccharides by enzymes mined directly from the marine metagenome., Carbohydrate Polymers, 2020, 234: 115909.

    9.Zhang, Pingxian, Wang, Yifan, Chachar, Sadaruddin, Tian, Jian* and Gu, Xiaofeng* (2020) eRice: a refined epigenomic platform for japonica and indica rice. Plant biotechnology journal, 18, 1642-1644.

    10.Tian, Jian#，Woodard, Jaie#，Whitney, Anna，Shakhnovich, Eugene(*)，Thermal Stabilization of Dihydrofolate Reductaseusing Monte Carlo Unfolding Simulations and its Functional Consequences，PLoS Computational Biology, 2015, 2015, 11(4):e1004207.

    联系方式

    联系电话：010-62599910

    E-mail： tianjian@caas.cn

    （简历更新时间 2025-06-20）