个人信息

赵学明，1979年9月生，博士，研究员。2008年至今在中国农业科学院北京畜牧兽医研究所工作，主要从事家畜繁殖技术与胚胎工程研究，在规模化牧场高效繁殖与繁殖障碍防、胚胎体外胚胎生产和保存、胚胎基因组选择等领域取得一定进展。现任家畜胚胎工程与繁殖创新团队骨干专家，兼任FAO《动物遗传资源保存创新指南》标准修订专家、国家和北京科技专家库入库专家、中国畜牧兽医学会动物繁殖学分会常务理事、国际低温学会会员、国际生物样本库协会官方杂志《生物保存和生物银行》编委。

研究方向和成果

入所至今共主持国家重点研发计划政府间重点专项、国家奶牛产业技术体系繁殖技术岗位科学家项目、国家自然基金项目、政府采购项目、北京市自然基金等项目十余项，作为科研骨干参加国家自然科学基金国际（地区）合作研究项目、中国农业科学院科技创新工程、转基因重大专项、科技支撑项目等。

近年来发表论文60余篇，其中第一/通讯作者发表SCI论文30篇、中文核心期刊60篇。同时，出版专著5部，获授权国家发明专利10余项，参与制定标准4项。担任多个期刊审稿专家。

在研项目

1.国家奶牛产业技术体系-繁殖技术岗位科学家（CARS-35-15）

2.牦牛高原适应性状表型精准鉴定技术路线构建（125A0605）

代表性论文和专利

[1] Ayantoye JO, Yang B, Dong J, Feng X, Shahzad M, Kolachi HA, Wan P, Pan H, Zhao X. Single-cell RNA and DNA methylome profiling reveal liquid helium vitrification enhances porcine parthenogenetically activated blastocyst viability. BMC Genomics. 2026 Apr 2;27(1):462. doi:10.1186/s12864-026-12752-5. PMID:41928102.

[2] Ayantoye JO, Yang B, Zhang H, Dong J, Zhang X, Song H, Shahzad M, Kolachi HA, Osaiyuwu OH, Wan P, Pan H, Zhao X. Overcoming the warming bottleneck in animal vitrification: Volumetric heating and enabling technologies for reproductive cryobanking. Prog Biophys Mol Biol. 2026 Mar;199:31-45. doi:10.1016/j.pbiomolbio.2025.11.003. Epub 2025 Dec 2. PMID:41344488.

[3] Zhang H, Gahallah S, Liu Y, Wang J, Zhang Z, Zhao X, Wan P. Melatonin improves the development ability of sheep embryos by reducing ROS during IVEP. Reprod Domest Anim. 2025 May;60(5):e70061. doi:10.1111/rda.70061.

[4] Zhang H, Yang B, Zhang P, Cao J, Zhang X, Gahallah S, Roth Z, Wan P, Zhao X. Combined treatment with IGF1, CoQ10, and melatonin improves the quality of bovine oocytes and heat-shocked blastocysts. Biology of Reproduction. 2025;113(2):307–320. doi:10.1093/biolre/ioaf123.

[5] Ayantoye JO, Yang B, Zhang H, Dong J, Zhang X, Song H, Shahzad M, Kolachi HA, Aderibigbe DO, Osaiyuwu OH, Wan P, Pan H, Zhao X. Ferroptosis-driven cryoinjury in porcine testicular tissue: Mechanisms, antioxidant-based cryoprotection, and translational strategies for fertility preservation. Anim Reprod Sci. 2026 Apr;287:108113. doi:10.1016/j.anireprosci.2026.108113. PMID:4157687

[6] Yang B, Hao T, Yang S, Hao H, Du W, Zhu H, Zhang P, Zhao X. Study on the expression patterns and function of JUNO and CD9 in bovine oocytes during in vitro maturation. Reprod Domest Anim. 2022 Sep 15. doi: 10.1111/rda.14262. Epub ahead of print. PMID: 36107170.

[7] Zhang P, Yang B, Xu X, Zhang H, Feng X, Hao H, Du W, Zhu H, Li S, Yu W, Khan A, Umer S, Zhao X. Combination of CNP, MT and FLI during IVM Significantly Improved the Quality and Development Abilities of Bovine Oocytes and IVF-Derived Embryos. Antioxidants (Basel). 2023;12(4):897.

[8] Xu X, Yang B, Zhang H, Feng X, Hao H, Du W, Zhu H, Khan A, Khan MZ, Zhang P, Zhao X. Effects of β-Nicotinamide Mononucleotide, Berberine, and Cordycepin on Lipid Droplet Content and Developmental Ability of Vitrified Bovine Oocytes. Antioxidants (Basel). 2023;12(5):991.

[9] Yang B, Hao T, Yang S, Hao H, Du W, Zhu H, Zhang P, Zhao X. Study on the expression patterns and function of JUNO and CD9 in bovine oocytes during in vitro maturation. Reprod Domest Anim. 2023;58(1):81-88.

[10] Zhang P, Yang S, Zhang H, Hao H, Du W, Wang J, Hao T, Zhu H, Umer S, Zhao X. Vitrification of bovine germinal vesicle oocytes significantly decreased the methylation level of their in vitro derived MII oocytes. Reprod Fertil Dev. 2022;34(13):889-903.

[11] Zhang P, Yang S, Zhang H, Hao H, Du W, Wang J, Hao T, Zhu H, Umer S, Zhao X. Vitrification of bovine germinal vesicle oocytes significantly decreased the methylation level of their in vitro derived MII oocytes. Reprod Fertil Dev. 2022;34(13):889-903.

[12] Hao T, Xu X, Hao H, Du W, Pang Y, Zhao S, Zou H, Yang S, Zhu H, Yang Y, Zhao X. Melatonin improves the maturation and developmental ability of bovine oocytes by enhancing gap junction intercellular communication via up-regulating GJA4 expression. Reprod Fertil Dev. 2021;33(14)：760-771.

[13] Hao T, Zhang P, Hao H, Du W, Pang Y, Zhao S, Zou H, Zhu H, Yu W, Li S, Zhao X. The combination treatment of cholesterol-loaded methyl-β-cyclodextrin and methyl-β-cyclodextrin significantly improves the fertilization capacity of vitrified bovine oocytes by protecting fertilization protein JUNO. Reprod Domest Anim. 2021;56(3):519-530.

[14] Zhang PP, Wang JJ, Li CY, Hao HS, Wang HY, Du WH, Pang YW, Zhao SJ, Zou HY, Hao T, Yang S, Ruan WM, Huan JM, Jiao PC, Zhu HB, Zhao XM*. Protective effect of vitamin C and lycopene on the in vitro fertilization capacity of sex-sorted bull sperm by inhibiting the oxidative stress. Reprod Domest Anim. 2020;55(9):1103-1114.

[15] Zhao YH, Wang JJ, Zhang PP, Hao HS, Pang YW, Wang HY, Du WH, Zhao SJ, Ruan WM, Zou HY, Hao T, Zhu HB, Zhao XM*. Oocytes in vitro maturation or vitrification significantly impaired DNA methylation patterns in their blastocysts analyzed by single cell whole genome methylation sequencing. Reprod Fertile Dev,2020; 32(7) 676-689.

[16] Li CY, Zhao YH, Hao HS, Wang HY, Huang JM, Yan CL, Du WH, Pang YW, Zhang PP, Liu Y, Zhu HB, Zhao XM*. Resveratrol significantly improves the fertilization capacity of bovine sex-sorted semen by inhibiting apoptosis and lipid peroxidation. Sci Rep. 2018; 8(7603).

       代表性专利

[1] 一种提高夏季条件下奶牛定时输精效率的方法. 专利号：ZL202510212418.7

[2] 用于牛体外胚胎生产的高效玻璃化冷冻方法. 专利号：ZL202210101366.2

[3] 一种调控冷冻牛卵母细胞的发育能力的方法及其应用. 专利号：ZL202111555409.6

联系方式

联系电话：010-62815892   E-mail：zhaoxueming@caas.cn

（简历更新时间 2026-09-20）