一、个人信息

关菲菲，女，1988年9月生，河北廊坊人，博士，副研究员，博士生导师。2012年7月获西南大学学士学位；2017年7月获中国科学院微生物研究所博士学位。2017年8月至2026年10月在中国农业科学院生物技术研究所做博后并工作，2026年11月至今在中国农业科学院北京畜牧兽医研究所工作。入选中国农业科学院“农科英才工程”-优秀青年英才，荣获昇腾AI创新大赛区域赛金奖和全国赛银奖。

二、研究方向与成果

主要从事蛋白智能分子设计研究工作，致力于基因编辑蛋白的挖掘与智能设计，以提升编辑系统的编辑效率与准确性、降低脱靶率，并增强其产业应用价值。

三、在研项目

1. 国家自然科学基金面上项目：抑制革兰氏阴性菌饲用抗菌肽的智能设计及其分子机制（编号：32472945）

四、代表性论文

1.Xu, Guoshun, Li, Suzhen, Li, Haoyu, Ren, Xiaopu, Ding, Yekun, Pang, Xinli, Liu, Xu, Tang, Qiaoling, Tu, Tao, Wang, Yuan, Luo, Huiying, Yao, Bin, Tian, Jian*, Chen, Rumei* and Guan, Feifei*. CasMiner: a deep-learning tool for high-throughput mining and rational design of efficient Cas9. National Science Review 2026, 13(6): nwag090.

2. Zhang, Ruohan#, Zhang, Yiyang#, Deng, Zhonghao#, Wang, Pengtao#, Fan, Lingxi, Guo, Feng, Luo, Huiying, Wang, Yuan, Tu, Tao, Yao, Bin, Tian, Jian*, Huang, Huoqing *, Li, Ming*, Guan, Feifei* (2026). A deep learning and generative modeling pipeline for mining and engineering alkaline-stable xylanases. Bioresource Technology. 460:135309. 

3. Guan, Feifei#, Ding, Yekun#, Xu, Guoshun#, Fan, Lingxi, Gu, Xiaofeng, Wang, Yuan, Luo, Huiying, Yao, Bin, Tian, Jian *. Engineering high-efficiency mutants of the transposase ISDra2 TnpB via protein generative models and energy-optimized design (2026), aBIOTECH. 7(2): 100027.

4. Gao, Han#, Guan, Feifei#, Luo, Boyu#, Zhang, Dongdong#, Liu, Wei#, Shen, Yuying, Fan, Lingxi, Xu, Guoshun, Wang, Yuan, Tu, Tao, Wu, Ningfeng, Yao, Bin, Luo, Huiying *, Teng, Yue*, Tian, Jian*, Huang, Huoqing*. DLFea4AMPGen de novo design of antimicrobial peptides by integrating features learned from deep learning models. Nature Communications 2025, 16(1):9134.

5. Liu, Tuoyu#, Zhang, Yiyang#, Li, Yanjun, Xu, Guoshun, Gao, Han, Wang, Pengtao, Tu, Tao, Luo, Huiying, Wu, Ningfeng, Yao, Bin, Liu, Bo*, Guan, Feifei*, Huang, Huoqing*, Tian, Jian*. Effective gene expression prediction and optimization from protein sequences. Advanced Science. 2025.

6. Wang, Zhe, Liu, Tuoyu, Xu, Guoshun, Gao, Han, Zhang, Ruohan, Zhang, Honglian, Zhang, Guijie, Wu, Ningfeng, Yao, Bin, Luo, Huiying*, Guan, Feifei*, Tian, Jian*. MPCutter: Predicting Protease-specific Substrate Cleavage Sites Using a Protein Language Model. Genomics Proteomics Bioinformatics 2025.

7.Miao, Ruiju, Xu, Guoshun, Ding, Yekun, Ding, Zundan, Woodard, J., Tu, Tao, Luo, Huiying., Wu, Ningfeng, Yao, Bin, Guan, Feifei*, Tian, Jian*. Engineering dual-functional and thermophilic BMHETase for efficient degradation of polyethylene terephthalate. Bioresource Technology 2024. 414:131556.

8. Guan, Feifei#, Tian, Xiaoqian#, Zhang, Ruohan#, Zhang, Yan, Wu, Ningfeng, Sun, Jilu, Zhang, Honglian, Tu, Tao, Luo, Huiying, Yao, Bin, Tian, Jian*, Huang, Huoqing*. Enhancing the endo-activity of the thermophilic chitinase to yield chitooligosaccharides with high degrees of polymerization. Bioresources and Bioprocessing 2024, 11 (1), 29.

9. Liu, Hanqing#, Guan, Feifei#*, Liu, Tuoyu#, Yang, Lixin#, Fan, Lingxi, Liu, Xiaoqing, Luo, Huiying, Wu, Ningfeng, Yao, Bin, Tian, Jian*, Huang, Huoqing*: MECE: a method for enhancing the catalytic efficiency of glycoside hydrolase based on deep neural networks and molecular evolution. Science Bulletin 2023, 68:2793-2805

10. Guan, Feifei#; Han, Yanshuo#; Yan, Kai; Zhang, Yan; Zhang, Zhifang; Wu, Ningfeng*; Tian, Jian*; Highly efficient production of chitooligosaccharides by enzymes mined directly from the marine metagenome., Carbohydrate Polymers, 2020, 234: 115909.

联系方式

E-mail: guanfeifei@caas.cn

（简历更新时间2026年11月3日）