研究方向与成果

家畜种质资源精准鉴定和优异性状形成机制深度解析。对我国绵羊、山羊、家马等地方品种资源的群体结构和进化关系进行研究，发现瘦肉型猪肌肉生长、脂尾羊脂肪沉积、家马体尺大小、绒山羊产绒长度等重要经济性状的新功能基因和分子标记15个；发现藏区家畜高海拔低氧适应性状的新功能基因和分子标记6个。近年来以第一或通讯作者在Current Biology (2022)、Molecular Biology and Evolution (2019)、PLoS Genetics (2021)、FASEB Journal (2019)等国际著名期刊发表SCI论文32篇。授权中国（国际）发明专利10项，联合培育藏西北白绒山羊新品种1个，获内蒙古自治区科技进步二等奖（2019），畜禽亲缘关系鉴定（牛、绵羊、马）技术通过国际遗传学会ISAG认证，盐池滩羊品种鉴定技术已推广应用19.3万只。

在研项目

1. 国家自然科学基金优秀青年项目，2023-2025，负责人

2. 国家自然科学基金国际（地区）合作研究项目，2020-2024，负责人

3. 国家重点研发项目子课题，2021-2025，子课题负责人

4. 农业农村部畜禽精准鉴定专项-山羊分子身份证构建，2021-2023，负责人

代表性论文和专利

1. Liu XX (#), Zhang YL (#), Liu WJ, Li YF, Pan JF, Pu YB, Han JL, Orlando L (*), Ma YH (*), Jiang L (*). A single-nucleotide mutation within the TBX3 enhancer increased body size in Chinese horses. Current Biology, 2022,32(2):480-487

2. Liu XX (#), Zhang YL (#), Li YF (#), Pan JF, Wang DD, Chen WH, Zheng ZQ, He XH, Zhao QJ, Pu YB, Guan WJ, Han JL, Orlando L (*), Ma YH (*), Jiang L (*). EPAS1 gain-of-function mutation contributes to high-altitude adaptation in Tibetan horses. Molecular Biology & Evolution, 2019, 36(11):2591-2603. (cover paper)

3. Wang DD (#), Pan DK (#), Xie BC (#), Wang SN, Xing XY, Liu XX, Ma YH, Andersson L, Wu JW (*), Jiang L (*). Porcine ZBED6 regulates growth of skeletal muscle and internal organs via multiple targets. PLoS Genetics, 2021, 17(10):e1009862.

4. Wang X (#), Jiang L (#), Wallerman O, Younis S, Yu Q, Klaesson A, Tengholm A, Welsh N, Andersson L. ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells. FASEB Journal, 2019, 33(1):88-100.

5. Markljung E (#), Jiang L (#), Jaffe JD, Mikkelsen TS, Wallerman O, et al., Andersson L (*). ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. PLoS Biology, 2009, 7:e1000256.

6. Wang X, Jiang L, Wallerman O, Engström U, Ameur A, Gupta R, Qi Y, Andersson L (*), Welsh N (*). The transcription factor ZBED6 affects gene expression, proliferation and cell death in pancreatic beta-cells. Proc Natl Acad Sci U S A, 2013, 110:15997-16002.

7. Han J(#), Ma S(#), Liang B, Bai T, Zhao Y, Ma Y, MacHugh D, Ma L(*) and Jiang L(*). Transcriptome profiling of developing ovine fat tail tissue reveals an important role for MTFP1 in regulation of adipogenesis. Frontiers in Cell and Developmental Biology, 2022,10:839731

8. Song S, Yao N, Yang M, Liu X, Dong K, Zhao Q, Pu Y, He X, Guan W, Yang N, Ma Y (*), Jiang L (*). Exome sequencing reveals genetic differentiation due to high-altitude adaptation in the Tibetan cashmere goat (Capra hircus). BMC Genomics, 2016, 17:122.

9. Wang Y, Zhang C, Wang N, Li Z, Heller R, Liu R, Zhao Y, Han J, Pan X, Zheng Z, Dai X, Chen C, Dou M, Peng S, Chen X, Liu J, Li M, Wang K, Liu C, Lin Z, Chen L, Hao F, Zhu W, Song C, Zhao C, Zheng C, Wang J, Hu S, Li C, Yang H, Jiang L, Li G, Liu M, Sonstegard TS, Zhang G, Jiang Y, Wang W, Qiu Q. Science, 2019, 364(6446):eaav6335.

10. Rubin CJ, Zody MC, Eriksson J, Meadows JR, Sherwood E, Webster MT, Jiang L, Ingman M, Sharpe T, Ka S, Hallböök F, Besnier F, Carlborg O, Bed'hom B, Tixier-Boichard M, Jensen P, Siegel P, Lindblad-Toh K, Andersson L. Nature, 2010, 464(7288):587-91.

联系方式

联系电话：010-62876899    E-mail： jianglin@caas.cn