专家队伍

Expert Team

  个人信息

  朱鸿飞,1965年12月生,江苏涟水人,预防兽医学博士,研究员,博士生导师。主要从事动物免疫佐剂和新型疫苗研究、重大动物疫病和外来动物疫病防控技术研究,现任兽医公共卫生安全与管理团队首席科学家。

  研究方向和成果

  主要研究方向为新型动物免疫佐剂研制、非洲猪瘟病毒基因缺失活疫苗候选株和表达ASFV 保护性抗原重组腺病毒、伪狂犬病毒和猪痘病毒活载体疫苗候选毒株创制、非洲猪瘟新型快速诊断技术研究、非洲猪瘟致病与免疫分子机制研究、牛结核病等人畜共患病新型诊断技术开发及综合防控研究等。目前已获得国家二类新兽药证书1项,发表论文50余篇,其中SCI论文20余篇,获得8项国家发明专利。

  在研项目

  1.国家重点研发计划,非洲猪瘟等外来动物疫病防控科技支撑(编号:2018YFC0840402)

  2.院级统筹工作专项,表达保护性抗原的病毒活载体疫苗创制(编号:Y2019YJ07-05)

  代表性论文和专利

  

  专利:

  1. 用于检测牛分枝杆菌感染的基因工程制剂(ZL201210146722.9)2. 重组蛋白混合物介导的牛结核病诊断方法及其试剂(ZL201210147131.3) 3. 含重组蛋白混合物的牛结核病检测试剂(ZL201210147678.3) 4. 区分牛病原性和非病原性分枝杆菌感染的试剂盒及方法(ZL200910081829.8)  5. 重组融合蛋白介导的牛分枝杆菌感染检测试剂盒及方法(ZL200910081828.3)

  论文:

  1. Liu S, Jia H, Hou S, Xin T, Guo X, Zhang G, Gao X, Li M, Zhu W, Zhu H*. Recombinant Mtb9.8 of Mycobacterium bovis stimulates TNF-α and IL-1β secretion by RAW264.7 macrophages through activation of NF-κB pathway via TLR2. Sci Rep. 2018. 8(1):1928.

  2. Hou Q, Hou S, Chen Q, Jia H, Xin T, Jiang Y, Guo X, Zhu H*. Nuclear localization signal regulates porcine circovirus type 2 capsid protein nuclear export through phosphorylation. Virus Res. 2018. 246:12-22.

  3. Jia H, Liu S, Wu J, Hou S, Xin T, Guo X, Yuan W, Gao X, Zhang G, Li M, Qu H, Zhu H*. Recombinant TB9.8 of Mycobacterium bovis Triggers the Production of IL-12 p40 and IL-6 in RAW264.7 Macrophages via Activation of the p38, ERK, and NF-κB Signaling Pathways. Inflammation. 2015. 38(3):1337-46.

  4. Liu S, Jia H, Hou S, Zhang G, Xin T, Li H, Yuan W, Guo X, Gao X, Li M, Wu J, Zhu H*. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-κB pathways via TLR2. Mol Immunol. 2014. 62(1):227-34.

  5. Xin T, Jia H, Ding J, Li P, Yang H, Hou S, Yuan W, Guo X, Wang H, Liang Q, Li M, Wang B, Zhu H*. Assessment of a protein cocktail-based skin test for bovine tuberculosis in a double-blind field test in cattle. Clin Vaccine Immunol. 2013. 20(4):482-90.

  6. Li Y, Sun A, Su S, Zhao P, Cui Z, Zhu H*. Deletion of the Meq gene significantly decreases immunosuppression in chickens caused by pathogenic Marek's disease virus. Virol J. 2011. 8:2.

  7. Guo X, Jia H, Zhang Q, Yuan W, Zhu G, Xin T, Zhu H, Sánchez-Vizcaíno JM. CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine. Microbiol Immunol. 2012, 56(5):332-7.

  8. Guo X, Jia H, Yuan W, Zhang Q, Hou S, Sun Y, Zhu G, Zhu H, Sánchez-Vizcaíno JM. Construction of swine-specific CpG motif enriched plasmid and the study of its immunostimulatory effects both in vitro and in vivo. J Vet Med Sci. 2012, 74(12):1647-50.

  9. Guo X, Zhang Q, Hou S, Zhai G, Zhu H, Sánchez-Vizcaíno JM. Plasmid containing CpG motifs enhances the efficacy of porcine reproductive and respiratory syndrome live attenuated vaccine. Vet Immunol Immunopathol. 2011, 144(3-4):405-9.

  联系方式

  联系电话:010-62819061 E-mail:bioclub@vip.sina.com