一、研究方向

1、家畜环境营养与健康养殖研究

针对我国畜禽养殖病死率高，过度用药造成产品质量安全隐患严峻的重大问题，秉承“畜禽健康是养出来的”的理念，在畜禽养殖饲料端全面“禁抗”的时代大背景下，团队创建畜禽“营养—环境—健康”机制及其调控研究平台，深入探究不同环境因子对畜禽行为、代谢、免疫、生产、肉蛋奶品质的影响机制，建立精准环境营养调控模型；深入研究幼龄家畜、特色地方畜禽品种在关键生理阶段肠道健康、免疫稳态、繁殖健康的动态变化规律及机制，针对性设计营养干预策略及开发配套产品；探究多酚、黄酮、特征寡糖等天然功能成分、益生菌等对畜禽生长和健康的影响，研发畜禽绿色饲料，服务畜禽健康养殖。

2、非粮饲料资源开发及粮饲联产技术

粮食安全的核心是饲料粮安全，突出表现在现代畜牧业生产“耗粮”比重越来越大，我国工农业副产物等非粮资源种类多、数量大，大量茎叶等绿色营养体未及时收获、利用，团队开发非粮饲料资源高值高效利用技术及配套产品，创建非粮饲料养分效价“精准快廉”评定方法，创新粮饲联产农机、农艺、农技技术和生产模式，开发非常规粮饲料原料的多元化配方决策系统，实现畜禽饲料的“节粮、降本、增效”。

二、代表性成果

1、仔猪健康养殖营养饲料调控技术及应用，国家科学技术进步二等奖，2011年。

2、单胃动物仿生消化系统及基于该系统模拟单胃动物消化的方法，中国专利奖优秀奖，2015年。

3、张宏福/动物营养与环境创新团队，全国农业科研杰出人才及其创新团队，2015年。

4、家畜营养与调控科技创新团队，中华农业科技奖优秀创新团队，2017年。

5、肉鸡绿色养殖提质技术研发与集成应用，中国产学研合作创新成果一等奖，2019年。

6、优质种猪选育及高效生产技术体系示范，天津市科技进步奖二等奖. 2021

7、肉鸡绿色养殖提质技术研发与集成应用，神农中华农业科技成果一等奖，2021年。

8、2019-2021年度全国农牧渔业丰收奖，全国农牧渔业丰收奖推广贡献奖，2022年。

9、Zhang P, Liu J, Xiong B, et al. Microbiota from alginate oligosaccharide-dosed mice successfully mitigated small intestinal mucositis. Microbiome. 2020, 8(112).

10、Zhao Y, Zhang P, Ge W, et al. Alginate oligosaccharides improve germ cell development and testicular microenvironment to rescue busulfan disrupted spermatogenesis. Theranostics, 2020, 10(7): 3308-3324.

11、Zhao Y, Feng Y, Liu M, et al. Single-cell RNA sequencing analysis reveals alginate oligosaccharides preventing chemotherapy-induced mucositis. Mucosal Immunology. 2020, 13(3): 437-448.

12、Tang S, Xie J, Wu W, et al. High ammonia exposure regulates lipid metabolism in the pig skeletal muscle via mTOR pathway. Science of the Total Environment, 2020, 20; 740:139917.

13、Zhang P, Feng Y, Li L, et al. Improvement in sperm quality and spermatogenesis following faecal microbiota transplantation from alginate oligosaccharide dosed mice. Gut. 2021, 70(1), 222-225.

14、Zhang C, Xiong B, Chen L, et al. Rescue of male fertility following faecal microbiota transplantation from alginate oligosaccharide-dosed mice. Gut. 2021, 70(11), 2213-2215.

15、Han H, Yi B, Zhong R, et al. From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators. Microbiome. 2021, 9(1):162.

16、Liu Z, Chen L, Gao X, et al. Quantitative proteomics reveals tissue-specific toxic mechanisms for acute hydrogen sulfide-induced injury of diverse organs in pig. Science of the Total Environment, 2021, 806(pt1):150365.

17、Liu Z, Zhong R, Li K, et al. Evaluation of energy values of high-fiber dietary ingredients with different solubility fed to growing pigs using the difference and regression methods. Animal nutrition. 2021,7(2):569-575.

18、Xia B, Zhong R, Wu W, et al. Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model. Microbiome. 2022, 31;10(1):139.

19、Xia B, Zhong R, Meng Q, et al. Multi-omics unravel the compromised mucosal barrier function linked to aberrant mucin O-glycans in a pig model. Int J Biol Macromol. 2022, 15;207:952-964.

20、Tang S, Chen Y, Deng F, et al. Xylooligosaccharide-mediated gut microbiota enhances gut barrier and modulates gut immunity associated with alterations of biological processes in a pig model. Carbohydrate Polymers. 2022, 15;294:119776.

21、Wo Y, Ma F, Shan Q, et al. Plasma metabolic profiling reveals that chromium yeast alleviates the negative effects of heat stress in mid-lactation dairy cows. Animal Nutrition.2023,13,401-410.

22、Gao J, Cui Y, Bao W, et al. Ubiquitylome study reveals the regulatory effect of α-lipoic acid on ubiquitination of key proteins in tryptophan metabolism pathway of pig liver. International Journal of Biological Macromolecules, 2023, 236: 123795.

23、Wu S, Tan J, Zhang H, et al. Tissue-specific mechanisms of fat metabolism that focus on insulin actions. Journal of Advanced Research. 2023, 53:187-198.

24、Zhang S, Tang S, Liu Z, et al. Baicalin restore intestinal damage after early-life antibiotic therapy: the role of the MAPK signaling pathway. Pharmacological Research. 2024, 204:107194.

25、Zhang S, Zhong R, Tang S, et al. Metabolic regulation of the Th17/Treg balance in inflammatory bowel disease. Pharmacological Research. 2024, 203:107184.

三、创新团队成员

团队首席：陈亮         资深首席：张宏福

骨干：顾宪红、孙鹏、郝月、伊宝、钟儒清

助理：马腾、张连华