专家队伍

Expert Team

个人信息

涂涛,1988年7月生,湖北省荆州市人,博士,副研究员,硕士生导师。2016年获中国农业科学院生物化学与分子生物学理学博士学位。2016年-2020年在中国农业科学院饲料研究所工作,2020年至今在中国农业科学院北京畜牧兽医研究所工作。主要从事饲用酶的结构与功能关系研究,现任饲用酶工程科技创新团队骨干专家;《Bioengineered》和《微生物学通报》编委;国家优秀青年科学基金获得者(2022年)和国家重点研发计划青年科学家项目主持人(2021年)。

研究方向与成果

一直从事饲用酶工程相关的研究工作,综合饲用酶的分子生物学、结构生物学和生物信息学等技术,通过对饲用酶结构与功能关系研究,致力于解决饲用酶性能差、难以满足饲料工业应用需求的根本性难题。主持各类科研项目9项,发表科研论文75篇,其中以第一作者或通讯作者(含并列)发表SCI收录论文27篇。以主要完成人身份申请国家发明专利35件(含PCT专利4件),获得授权21件。

在研项目

1. 国家自然科学基金优秀青年科学基金项目,2023.01-2025.12,200万元,主持

2. 国家重点研发计划青年科学家项目,2021.07-2024.06,400万元,主持

3. 国家自然科学基金面上项目,2021.01-2024.12,69.60万元,主持

代表性论文和专利

1. Ding S., Liu X., Hakulinen N., Taherzadeh M. J., Wang Y., Wang Y., Qin X., Wang X., Yao B., Luo H., Tu T.* Boosting enzymatic degradation of cellulose using a fungal expansin: Structural insight into the pretreatment mechanism. Bioresource Technology 2022, 358: 127434.

2. Wang S.,† Ding S.,† Meng K., Liu X., Wang Y., Wang X., Qin X., Luo H., Yao B., Huang H.*, Tu T.* Preparation of methyl-esterified pectin oligosaccharides with antibacterial activity using fungus-derived bifunctional pectinase. Journal of Cleaner Production 2022, 333: 130110.

3. Liang Z., Yan Y., Zhang W., Luo H., Yao,B., Huang H.*, Tu T.* Review of glucose oxidase as a feed additive: production, engineering, applications, growth-promoting mechanisms, and outlook. Critical reviews in biotechnology 2022, DOI: 10.1080/07388551.2022.2057275.

4. Wang Q., Liu X., Tian J., Wang Y., Zhang H., Wang Y., Luo H., Yao B., Huang H.*, Tu T.* Enhancing the thermostability of phytase to boiling point by evolution-guided design. Applied and Environmental Microbiology 2022, e0050622. (Featured Image)

5. Sun L., Bai Y., Zhang X., Zhou C., Zhang J., Su X., Luo H., Yao B., Wang Y.*, Tu T.* Characterization of three glutamate decarboxylases from  Bacillus spp. for efficient γ-aminobutyric acid production. Microbial Cell Factories 2021, 20: 153.

6. Wang S.,† Meng K.,† Su X., Hakulinen N., Wang Y., Zhang J., Luo H., Yao B., Huang H.*, Tu T.* Cysteine engineering of an endo-polygalacturonase from  Talaromyces leycettanus JCM 12802 to improve its thermostability. Journal of Agricultural and Food Chemistry 2021, 69, 6351−6359.

7. Tu T., Wang Z., Luo Y., Li Y., Su X., Wang Y., Zhang J., Rouvinen J., Yao B., Hakulinen N.*, Luo H.* Structural insights into the mechanisms underlying the kinetic stability of GH28 endo-polygalacturonase. Journal of Agricultural and Food Chemistry 2021, 69(2):815-823.

8. Jiang X., Wang Y., Wang Y., Huang H., Bai Y., Su X., Zhang J., Yao B., Tu T.*, Luo H.* Exploiting the activity-stability trade-off of glucose oxidase from  Aspergillus niger using a simple approach to calculate thermostability of mutants. Food Chemistry 2021, 342:128270.

9. Ren Y., Luo H., Huang H., Hakulinenc N., Wang Y., Wang Y., Su X., Bai Y., Zhang J., Yao B., Wang G.*, Tu T.* Improving the catalytic performance of Proteinase K from  Parengyodontium album for use in feather degradation. International Journal of Biological Macromolecules 2020, 154:1586-1595.

10. Tu T., Wang Y., Huang H., Wang Y., Jiang X., Wang Z., Yao B., Luo H. Improving the thermostability and catalytic efficiency of glucose oxidase from  Aspergillus niger by molecular evolution. Food Chemistry 2019, 281:163-170.


    联系方式

    联系电话:010-62599910    E-mail: tutao@caas.cn

    (简历更新时间 2022-09-30)