专家队伍

Expert Team

个人信息

张杰,1983年12月生,山东省沂源县人,博士,研究员,博士生导师。2007年获青岛农业大学生物科学学士学位;2010年获中国农业科学院微生物学硕士学位;2015年获中国科学院大学生物化学与分子生物学博士学位;2015年-2019年在美国奥本大学从事博士后研究。2019年-2020年在中国农业科学院饲料研究所工作;2020年7月至今在中国农业科学院北京畜牧兽医研究所工作。主要从事基于合成生物学的畜牧业用生物活性制剂研究,现任饲用酶工程创新团队骨干专家。2020年入选中国农业科学院“青年英才计划”。

研究方向与成果

2019年以来,主要从事利用合成生物学技术进行畜牧业用生物活性物质高效生产的研究工作。以大肠杆菌、毕赤酵母等为出发菌株,通过基因工程、代谢工程、进化工程等,优化微生物细胞代谢网络,打通从基因组到产品的技术链条,提高畜牧业用生物活性物质的产率与效率,构建高效微生物细胞工厂。

在研项目

1. 国家自然科学基金面上项目“基于丙酮酸途径的饲用L-异亮氨酸细胞工厂构建及适配机制研究”(编号:32172767)

2. 国家重点研发计划课题“新型氨基酸及其衍生物合成生物技术及产品创制”(课题编号:2021YFD1301001)

3. 牧医所创新工程所级重点任务“基于合成生物学的饲用抗生素替代品的研发及产品创制”

代表性论文和专利

1. Xiaolu Wang, Huiying Luo, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Xiaoyun Su, Huoqing Huang, Yingguo Bai, Bin Yao, Jie Zhang*. Direct conversion of carbon dioxide to glucose using metabolically engineered Cupriavidus necator. Bioresource Technology, 2022, 362:127806.

2. Qiquan Zhang#, Xiaolu Wang#, Huiying Luo, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Xiaoyun Su, Huoqing Huang, Bin Yao, Yingguo Bai*, Jie Zhang*. Metabolic engineering of Pichia pastoris for myo-inositol production by dynamic regulation of central metabolism. Microbial Cell Factories, 2022, 21:112.

3. Kaikai Wang#, Xiaolu Wang#, Huiying Luo, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Yingguo Bai, Huoqing Huang, Bin Yao, Xiaoyun Su*, Jie Zhang*. Synergetic fermentation of glucose and glycerol for high-yield N-acetylglucosamine production in Escherichia coli. International Journal of Molecular Sciences, 2022, 23:773.

4. Xiaolu Wang#, Xiaomin Zhao#, Huiying Luo, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Huoqing Huang, Yingguo Bai, Bin Yao, Xiaoyun Su*, Jie Zhang*. Metabolic engineering of Komagataella phaffii for synergetic utilization of glucose and glycerol. Yeast, 2022, 39:412-421.

5. Jun Feng#, Jie Zhang#, Yuechao Ma#, Yiming Feng, Shangjun Wang, Na Guo, Haijiao Wang, Pixiang Wang, Pablo Jiménez-Bonilla, Yanyan Gu, Junping Zhou, Zhong-Tian Zhang, Mingfeng Cao, Di Jiang, Shuning Wang, Xian-Wei Liu, Zengyi Shao, Ilya Borovok, Haibo Huang*, Yi Wang*. Renewable fatty acid ester production in  Clostridium . Nature Communications, 2021, 12(1):4368.

6. Xiuqing Zhou#, Xiaolu Wang#, Huiying Luo, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Xiaoyun Su, Yingguo Bai, Bin Yao, Huoqing Huang*, Jie Zhang*. Exploiting heterologous and endogenous CRISPR-Cas systems for genome editing in the probiotic  Clostridium butyricum . Biotechnology and Bioengineering, 2021, 118(7): 2448-2459.

7. Jie Zhang#, Wei Hong#, Liang Guo, Yifen Wang, Yi Wang. Enhancing plasmid transformation efficiency and enabling CRISPR-Cas9/Cpf1-based genome editing in  Clostridium tyrobutyricum . Biotechnology and Bioengineering, 2020, 117(9): 2911-2917.

8. Jie Zhang, Wenming Zong, Wei Hong, Zhong-Tian Zhang, Yi Wang. Exploiting endogenous CRISPR-Cas system for multiplex genome editing in Clostridium tyrobutyricum and engineer the strain for high-level butanol production. Metabolic Engineering, 2018, 47:49-59.

9. Jie Zhang, Pixiang Wang, Xiaofei Wang, Jun Feng, Hardev S. Sandhu, Yi Wang. Enhancement of sucrose metabolism in  Clostridium saccharoperbutylacetonicum  N1-4 through metabolic engineering for improved acetone–butanol–ethanol (ABE) fermentation. Bioresource Technology, 2018, 270:430-438.

10. Wei Hong#, Jie Zhang#, Guzhen Cui, Luxin Wang, Yi Wang. Multiplexed CRISPR-Cpf1-mediated genome editing in  Clostridium difficile toward the understanding of pathogenesis of  C. difficile infection. ACS synthetic biology, 2018, 7(6):1588-1600.


    联系方式

    联系电话:010-62599910    E-mail:zhangjie09@caas.cn

    (简历更新时间 2022-09-30)