一、研究方向

　　1、饲料养分效价评定和高效利用研究

　　团队紧扣养殖业发展产业重大需求，系统研究了乳仔猪饲料配制及健康养殖技术、猪禽氨基酸生物学效价及其评定方法，服务于产业，丰富了中国饲料数据库。近年来，团队针对饲料有效能快速、准确评定这一前沿性难题，不断创新饲料可消化养分体外仿生评定方法和技术，创制了“单胃动物仿生消化系统”，实现饲料养分以及酶制剂效价快速、精准评定，为畜禽精准饲喂、促进动物健康、减少氮磷排放提供技术和理论支撑。

　　2、动物营养-环境-健康机制研究

　　针对我国畜禽养殖病死率高，过度用药造成产品质量安全隐患严峻的重大问题，秉承“畜禽健康是养出来的”的理念和面对“畜禽疾病主要是养出来的”生产实际难题，在畜禽养殖饲料端全面“禁抗”的时代大背景下，团队创建畜禽“营养—环境—健康”机制及其调控研究平台，打造学科交叉研究方向，旨在系统解析主要养殖环境因子影响畜禽生长和健康的机制，研发改善畜禽舍内环境和提高畜禽自身免疫的环境营养策略，实现畜禽健康养殖。

　　二、代表性成果

　　1、仔猪健康养殖营养饲料调控技术及应用，国家科学技术进步二等奖，2011年。

　　2、单胃动物仿生消化系统及基于该系统模拟单胃动物消化的方法，中国专利奖优秀奖，2015年。

　　3、张宏福/动物营养与环境创新团队，全国农业科研杰出人才及其创新团队，2015年。

　　4、家畜营养与调控科技创新团队，中华农业科技奖优秀创新团队，2017年。

　　5、猪禽饲料养分效价仿生消化评定技术的创建与应用，中国农业科学院青年科技创新奖，2017年。

　　6、肉鸡绿色养殖提质技术研发与集成应用，中国产学研合作创新成果一等奖，2019年。

　　7、Wei, J. Y., J. Wang, W. Liu, K. Z. Zhang, and P. Sun. "Effects of different selenium supplements on rumen fermentation and apparent nutrient and selenium digestibility of mid-lactation dairy cows." Journal of dairy science 102, no. 4 (2019): 3131-3135.

　　8、Chen, Liang, Ruqing Zhong, Lilan Zhang, and Hongfu Zhang. "The Chronic Effect of Transgenic Maize Line with mCry1Ac or maroACC Gene on Ileal Microbiota Using a Hen Model." Microorganisms 7, no. 3 (2019): 92.

　　9、S. J. Luan, Y. B. Sun, Y. Wang, R. N. Sa*, and H. F. Zhang. Bacillus amyloliquefaciens spray improves the growth performance, immune status, and respiratory mucosal barrier in broiler chickens. Poultry Science. 2019. 98:1403–1409.

　　10、Liu, Jingbo, Shanchuan Cao, Ming Liu, Liang Chen, and Hongfu Zhang. "A high nutrient dense diet alters hypothalamic gene expressions to influence energy intake in pigs born with low birth weight." Scientific reports 8, no. 1 (2018): 5514.

　　11、Zhang, Li, Weida Wu, Yuan-Kun Lee, Jingjing Xie, and Hongfu Zhang. "Spatial heterogeneity and co-occurrence of mucosal and luminal microbiome across swine intestinal tract." Frontiers in microbiology 9 (2018): 48.

　　12、Chen, L., L. X. Gao, Q. H. Huang, R. Q. Zhong, L. L. Zhang, X. F. Tang, and H. F. Zhang. "Viscous and fermentable nonstarch polysaccharides affect intestinal nutrient and energy flow and hindgut fermentation in growing pigs." Journal of animal science 95, no. 11 (2017): 5054-5063.

　　13、Sun, P., J. Wang, W. Liu, D. P. Bu, S. J. Liu, and K. Z. Zhang. "Hydroxy-selenomethionine: A novel organic selenium source that improves antioxidant status and selenium concentrations in milk and plasma of mid-lactation dairy cows." Journal of dairy science 100, no. 12 (2017): 9602-9610.

　　14、Wang, Yan, Kexin Wang, He Huang, Xianhong Gu, and Xiaohua Teng. "Alleviative effect of selenium on inflammatory damage caused by lead via inhibiting inflammatory factors and heat shock proteins in chicken testes." Environmental Science and Pollution Research 24, no. 15 (2017): 13405-13413.

　　15、Liu, Y., Jiao, X., Teng, X., Gu, X. and Teng, X., 2017. Antagonistic effect of selenium on lead-induced inflammatory injury through inhibiting the nuclear factor-κB signaling pathway and stimulating selenoproteins in chicken hearts. RSC Advances, 7(40), pp.24878-24884.

　　16、Hao, Yue, Yanjun Cui, and Xianhong Gu. "Genome-wide DNA methylation profiles changes associated with constant heat stress in pigs as measured by bisulfite sequencing." Scientific reports 6 (2016): 27507.

　　17、Yi, Bao, Liang Chen, Renna Sa, Ruqing Zhong, Huan Xing, and Hongfu Zhang. "High concentrations of atmospheric ammonia induce alterations of gene expression in the breast muscle of broilers (Gallus gallus) based on RNA-Seq." BMC genomics 17, no. 1 (2016): 598.

　　18、Wu, W., J. Xie, and H. Zhang. "Dietary fibers influence the intestinal SCFAs and plasma metabolites profiling in growing pigs." Food & function 7, no. 11 (2016): 4644-4654.

　　19、Zhao, F., M. L. Xie, H. Li, and H. F. Zhang. "Developing a silicon t-shaped cannula to sample intestinal digesta in ducks." Animal feed science and technology 219 (2016): 175-180.

　　20、Zhong, R. Q., L. Chen, L. X. Gao, L. L. Zhang, B. Yao, X. G. Yang, and H. F. Zhang. "Effects of feeding transgenic corn with mCry1Ac or maroACC gene to laying hens for 12 weeks on growth, egg quality and organ health." animal 10, no. 8 (2016): 1280-1287.

　　21、Zhao, F., L. Q. Ren, B. M. Mi, H. Z. Tan, J. T. Zhao, H. Li, H. F. Zhang, and Z. Y. Zhang. "Developing a computer-controlled simulated digestion system to predict the concentration of metabolizable energy of feedstuffs for rooster." Journal of animal science 92, no. 4 (2014): 1537-1547.

　　三、创新团队成员

团队首席：陈亮  资深首席：张宏福

骨干：顾宪红、孙鹏、郝月、伊宝

助理：刘蕾、马腾、钟儒清、张连华