动物资源与遗传育种研究室

鸡遗传育种科技创新团队

　　一、研究方向

　　1. 重要性状遗传机理解析

　　遵循“科学问题来自于生产实际”的原则，本团队以鸡、鸽重要性状的性能改良和品质提升为切入点，利用全基因组和转录组等组学、免疫学和分子生物学等技术，深入研究鸡、鸽种质资源特性。挖掘肉鸡脂肪沉积、产肉率、饲料报酬和风味等性状功能基因并解析遗传基础；筛选肉鸡宿主抗病功能基因并解析其作用机制；解析种公鸡精液品质、母鸡持续受精能力等繁殖性状和交叉喙遗传缺陷性状的分子和环境调控机制；开展蛋鸡繁殖性状杂种优势预测与分子调控机制等基础研究；解析雌雄鸽的泌乳调控机理及鸽毛滴虫寄生和免疫逃逸的分子机制。

　　2. 育种和其它应用技术研发

　　国内最早建立了肌内脂肪含量、肌苷酸含量、淋巴细胞比率的选育技术；国内最早建立了矮小型肉鸡配套制种技术，在30%的国家审定肉鸡新品种中得到应用；自主研发出国内首款“京芯一号”肉鸡基因组育种芯片，建立了肉鸡全基因组选择技术平台；建立了小型白羽肉鸡的育种技术，相关专利在企业成功转化；结合传统育种技术和分子标记辅助选育技术，创新了鸡受精能力选育技术和鸽BLUP育种技术，系统研发了肉鸡、蛋鸡和种鸡精准光照技术。

　　3. 新品种培育

　　利用优良地方鸡种、进口肉鸡或高产蛋鸡品种等遗传素材，与育种企业合作，创制专门化新品系，持续开展品系选育和配套系培育工作，培育了具有市场竞争力的黄羽肉鸡、特色蛋鸡和快速型白羽肉鸡新品种。节粮优质抗病育种技术体系为解决产业中优质高产高效问题提供了关键技术支撑。“栗园油鸡蛋鸡”和“京星黄鸡103”于2016年通过国家审定，有力推动了北京油鸡资源的开发利用；利用引进的肉鸽品种及特色地方品种等优势育种资源，开展肉鸽新品种培育，致力于解决肉鸽国家审定品种少、繁育体系不健全等产业问题。

　　二、代表性成果

　　1 育成新品种与科技奖励

　　育成肉鸡新品种（配套系）京星黄鸡100、京星黄鸡102、京星黄鸡103，与企业合作育成肉鸡新品种（配套系）五星黄鸡、金陵花鸡金陵黑凤鸡，育成栗园油鸡蛋鸡新品种（配套系）；获得国家科技进步二等奖2项，中华农业科技一等奖、全国农牧渔业丰收一等奖、安徽科学技术一等奖各1项。

　　2. 代表性论文与专著发表

　　1. Liu RR^#, Xing SY^#, Wang J, Zheng MQ, Cui HX, Richard PMA. Crooijmans, Li QH, Zhao GP^*, Wen J^*. A new chicken 55K SNP genotyping array. BMC Genomics. 2019, 20:410.

　　2. Li QH^#, Wang F^#, Wang Q, Zheng M, Liu RR, Cui HX, Wen J, Zhao GP^*. SPOP Promotes Ubiquitination and Degradation of MyD88 to Suppress the Innate Immune Response. BioRxiv. 831586; 2019.

　　3. Sun YY ^#, Fu L, Xue FG, Li YL, Xu H, Chen JL^*. Digital gene expression profiling and validation study highlight Cyclin F as an important regulator for sperm motility of chickens. Poultry Science. 2019, 98(10):5118–5126.

　　4. Sun YY ^#, Xue FG^#, Li YL, Fu L, Bai H, Ma H, Xu SS, Chen JL^*. Differences in semen quality, testicular histomorphology, fertility, reproductive hormone levels, and expression of candidate genes according to sperm motility in Beijing-You chickens. Poultry Science. 2019, 98(9):4182–4189.

　　5. Sun YY^#, Liu N, Bai H, Li YL, Xue FG, Ye JH, Ma H, En H, Chen JL^*. Differential proteomic analysis to identify proteins associated with beak deformity in chickens. Poultry Science. 2019, 98(4):1833-1841.

　　6. Shi L^#, Sun YY^#, Xu H, Liu YF, Li YL, Huang ZY, Ni AX, Chen C, Wang PL, Ye JH, Ma H, Li DL, Chen JL^*. Effect of age at photostimulation on reproductive performance of Beijing-You Chicken breeders. Poultry Science. 2019, 98(10): 4522–4529.

　　7. Liu YF^#, Sun YY^#, Li YL, Bai H, Xu SS, Xu H, Ni AX, Yang N, Chen JL^*. Identification and differential expression of microRNAs in the testis of chicken with high and low sperm motility. Theriogenology. 2018, 122:94-101.

　　8. Bai H^#, Sun YY^#, Liu N, Xue FG, Li YL, Xu SS, Ye JH, Zhang L, Chen Y, Chen JL^*. Single SNP- and pathway-based genomewide association studies for beak deformity in chickens using high-density 600K SNP arrays. BMC Genomics. 2018, 9(1):1471-2164.

　　9. Bai H^#, Sun YY^#, Liu N, Liu YF, Xue FG, Li YL, Xu SS, Ni AX, Ye JH, Chen Y, Chen JL^*. Genome-wide detection of CNVs associated with beak deformity in chickens using high-density 600K SNP arrays. Animal Genetics. 2018, 49(3):226-236.

　　10. Cui HX^#, Zheng MQ^#, Zhao GP, Liu RR, Wen J^*. Identification of differentially expressed genes and pathways for intramuscular fat metabolism between breast and thigh tissues of chickens. BMC Genomics. 2018, 19:55.

　　11. Wang Q^#, Li QH^#, Liu T, Chang GB, Sun ZH, Gao Z, Wang F, Zhou HJ, Liu RR, Zheng MQ, Cui HX, Chen GH, Li H, Yuan XY, Wen J, Peng DX^*, Zhao GP^*. HostInteraction Analysis of PA-N155 and PA-N182 in chicken cells reveals an essential role of UBA52 for replication of H5N1 avian influenza virus. Frontiers in Microbiology. 2018, 9(936):1.

　　12. Liu RR^#, Wang HY^#, Liu J, Wang J, Zheng MQ, Tan XD, Xing SY, Cui HX, Li QH, Zhao GP, Wen J^*. Uncovering the embryonic development-related proteome and metabolome signatures in breast muscle and intramuscular fat of fast-and slow-growing chickens. BMC Genomics. 2017, 18:816.

　　13. Liu YF^#, Sun YY^#, Li YL, Bai H, Xue FG, Xu SS, Xu H, Shi L, Yang N, Chen JL^*. Analyses of long non-coding RNA and mRNA profling using RNA sequencing in chicken testis with extreme sperm motility. Scientific Reports. 2017, 7(1):9055.

　　14. Li QH^#, Yuan XY^#, Wang Q, Chang GB, Wang F, Liu RR, Zheng MQ, Chen GH, Wen J, and Zhao GP^*. Interactomic landscape of PA-X-chicken protein complexes of H5N1 influenza A virus. Journal of Proteomics. 2016, 148:20-25.

　　15. Huang HY^#, Zhao GP, Liu RR, Li QH, Zheng MQ, Li SF, Liang Z, Zhao ZH, Wen J^*. Brain Natriuretic peptide stimulates lipid metabolism through its receptor NPR1 and the glycerolipid metabolism pathway in chicken adipocytes. Biochemistry. 2015, 54(43):6622-6630.

　　16. Cui HX^#, Zhao GP^#, Liu RR, Zheng MQ, Chen J, Wen J^*. FSH stimulates lipid biosynthesis in chicken adipose tissue by up-regulating the expression of its receptor FSHR, The Journal of Lipid Research. 2012, 53:(5) 909-917.

　　17.《肉鸡养殖轻简化技术图册》，赵桂苹主编，2017，金盾出版社。

　　18.《中国现代农业产业可持续发展战略研究-肉鸡分册》，文杰主编，2016, 中

　　国农业出版社。

　　19.《畜禽健康养殖》，文杰主编，2007, 中国农业出版社。

　　20.《图说高效养蛋鸡关键技术》，陈继兰、姜润深主编，2007, 金盾出版社。

　　三、创新团队成员