Progress on Mechanisms of miRNAs Regulating Salmonella Enteritidis Infection

　　Recently, chicken genetics and breeding team of the Institute of Animal Sciences in CAAS has achieved progress on the research of small RNAs regulating the host resistance against Salmonella Enteritidis (SE) infection. Multi-omics joint analysis was employed in the study, with SE resistance and SE susceptible chickens as materials. Key immune genes and small RNA were identified from spleen to play a critical role in host resistance against the infection of salmonella enteritidis. The latest achievement was published on Front Cell Infect Microbiol on August 24th, 2017(http://journal.frontiersin.org/article/10.3389/fcimb.2017.00377/full)..

　　Salmonella Enteritidis is a major pathogenic bacteria jeopardizing human intestinal health while chicken is considered as an important infection resource and carrier of this disease, so it will be of great importance to control poultry SE. The study totally identify 32 small RNAs of differential expression between SE resistance and the susceptible group, as well as 273 related target genes; Signaling pathways such as apoptosis and NOD receptor are remarkably enriched. Further study shows that gga-miR-101 and gga-miR-105 can individually bind to regulate IRF4 and LRRC59 genes and decrease the expression of proinflammatory factors. The study above indicates that miRNAs play important roles in regulating chicken immunity against Salmonella Enteritidis infection.

　　The study is supported by National Natural Science Foundation of China, National Key Technologies R&D Program of China, the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences. Mr. Li Peng from the Institute of Animal Sciences in CAAS is the first author and Prof. Wen Jie and Prof. Zhao Guiping are co-corresponding authors.